Microbiomes in respiratory health and disease: an Asia-Pacific perspective

Chotirmall, Sanjay H., Gellatly, Shaan L., Budden, Kurtis F., Mac Aogain, Micheál, Shukla, Shakti D., Wood, David L. A., Hugenholtz, Philip, Pethe, Kevin and Hansbro, Philip M. (2017) Microbiomes in respiratory health and disease: an Asia-Pacific perspective. Respirology, 22 2: 240-250. doi:10.1111/resp.12971


Author Chotirmall, Sanjay H.
Gellatly, Shaan L.
Budden, Kurtis F.
Mac Aogain, Micheál
Shukla, Shakti D.
Wood, David L. A.
Hugenholtz, Philip
Pethe, Kevin
Hansbro, Philip M.
Title Microbiomes in respiratory health and disease: an Asia-Pacific perspective
Journal name Respirology   Check publisher's open access policy
ISSN 1440-1843
1323-7799
Publication date 2017-02-01
Year available 2017
Sub-type Article (original research)
DOI 10.1111/resp.12971
Open Access Status Not yet assessed
Volume 22
Issue 2
Start page 240
End page 250
Total pages 11
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Subject 2740 Pulmonary and Respiratory Medicine
Abstract There is currently enormous interest in studying the role of the microbiome in health and disease. Microbiome's role is increasingly being applied to respiratory diseases, in particular COPD, asthma, cystic fibrosis and bronchiectasis. The changes in respiratory microbiomes that occur in these diseases and how they are modified by environmental challenges such as cigarette smoke, air pollution and infection are being elucidated. There is also emerging evidence that gut microbiomes play a role in lung diseases through the modulation of systemic immune responses and can be modified by diet and antibiotic treatment. There are issues that are particular to the Asia-Pacific region involving diet and prevalence of specific respiratory diseases. Each of these issues is further complicated by the effects of ageing. The challenges now are to elucidate the cause and effect relationships between changes in microbiomes and respiratory diseases and how to translate these into new treatments and clinical care. Here we review the current understanding and progression in these areas.
Keyword Asthma
Chronic obstructive pulmonary disease
Cystic fibrosis
Gut
Health
Microbiome
Mouse model
Prevention
Respiratory disease
Treatment
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID NMRC/TA/0048/2016
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
 
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Created: Sat, 21 Jan 2017, 00:18:46 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences