Bacterial community collapse: a meta-analysis of the sinonasal microbiota in chronic rhinosinusitis

Mackenzie, Brett Wagner, Waite, David W., Hoggard, Michael, Douglas, Richard G., Taylo, Michael W. and Biswas, Kristi (2017) Bacterial community collapse: a meta-analysis of the sinonasal microbiota in chronic rhinosinusitis. Environmental Microbiology, 19 1: 381-392. doi:10.1111/1462-2920.13632

Author Mackenzie, Brett Wagner
Waite, David W.
Hoggard, Michael
Douglas, Richard G.
Taylo, Michael W.
Biswas, Kristi
Title Bacterial community collapse: a meta-analysis of the sinonasal microbiota in chronic rhinosinusitis
Journal name Environmental Microbiology   Check publisher's open access policy
ISSN 1462-2920
Publication date 2017-01-18
Sub-type Article (original research)
DOI 10.1111/1462-2920.13632
Open Access Status Not yet assessed
Volume 19
Issue 1
Start page 381
End page 392
Total pages 12
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Chronic rhinosinusitis (CRS) is a common, debilitating condition characterized by long-term inflammation of the nasal cavity and paranasal sinuses. The role of the sinonasal bacteria in CRS is unclear. We conducted a meta-analysis combining and reanalysing published bacterial 16S rRNA sequence data to explore differences in sinonasal bacterial community composition and predicted function between healthy and CRS affected subjects. The results identify the most abundant bacteria across all subjects as Staphylococcus, Propionibacterium, Corynebacterium, Streptococcus and an unclassified lineage of Actinobacteria. The meta-analysis results suggest that the bacterial community associated with CRS patients is dysbiotic and ecological networks fostering healthy communities are fragmented. Increased dispersion of bacterial communities, significantly lower bacterial diversity, and increased abundance of members of the genus Corynebacterium are associated with CRS. Increased relative abundance and diversity of other members belonging to the phylum Actinobacteria and members from the genera Propionibacterium differentiated healthy sinuses from those that were chronically inflamed. Removal of Burkholderia and Propionibacterium phylotypes from the healthy community dataset was correlated with a significant increase in network fragmentation. This meta-analysis highlights the potential importance of the genera Burkholderia and Propionibacterium as gatekeepers, whose presence may be important in maintaining a stable sinonasal bacterial community.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online 18 January 2017

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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Created: Fri, 20 Jan 2017, 22:08:31 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences