An overview of structural features of antibacterial glycoconjugate vaccines that influence their immunogenicity

Khatun, Farjana, Stephenson, Rachel J. and Toth, Istvan (2017) An overview of structural features of antibacterial glycoconjugate vaccines that influence their immunogenicity. Chemistry - A European Journal, 23 18: 4233-4254. doi:10.1002/chem.201603599


Author Khatun, Farjana
Stephenson, Rachel J.
Toth, Istvan
Title An overview of structural features of antibacterial glycoconjugate vaccines that influence their immunogenicity
Journal name Chemistry - A European Journal   Check publisher's open access policy
ISSN 1521-3765
0947-6539
Publication date 2017-01-18
Sub-type Article (original research)
DOI 10.1002/chem.201603599
Open Access Status Not yet assessed
Volume 23
Issue 18
Start page 4233
End page 4254
Total pages 22
Place of publication Weinheim, Germany
Publisher Wiley - VCH
Collection year 2018
Language eng
Formatted abstract
Bacterial cell-surface-derived or mimicked carbohydrate moieties that act as protective antigens are used in the development of antibacterial glycoconjugate vaccines. The carbohydrate antigen must have a minimum length or size to maintain the conformational structure of the antigenic epitope(s). The presence or absence of O-acetate, phosphate, glycerol phosphate and pyruvate ketal plays a vital role in defining the immunogenicity of the carbohydrate antigen. The nature of the carrier protein, spacer and conjugation pattern used to develop the glycoconjugate vaccine also defines its overall spatial orientation which in turn affects its avidity and selectivity of interaction with the desired target(s). In addition, the ratio of carbohydrate to protein in glycoconjugate vaccines also makes an important contribution in determining the optimum immunological response. This Review article presents the importance of these variables in the development of antibacterial glycoconjugate vaccines and their effects on immune efficacy.
Keyword Carbohydrates
Spacer
Proteins
Glycoconjugates
Conjugation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online 18 January 2017

 
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Created: Fri, 20 Jan 2017, 21:59:28 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences