Salmonella-induced inflammasome activation in humans

Bierschenk, Damien, Boucher, Dave and Schroder, Kate (2016) Salmonella-induced inflammasome activation in humans. Molecular Immunology, 86 38-43. doi:10.1016/j.molimm.2016.11.009


Author Bierschenk, Damien
Boucher, Dave
Schroder, Kate
Title Salmonella-induced inflammasome activation in humans
Formatted title
Salmonella-induced inflammasome activation in humans
Journal name Molecular Immunology   Check publisher's open access policy
ISSN 1872-9142
0161-5890
Publication date 2016-12-11
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.molimm.2016.11.009
Open Access Status Not yet assessed
Volume 86
Start page 38
End page 43
Total pages 6
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Abstract Inflammasomes are macromolecular complexes that assemble upon recognition of pathogen- or danger-associated molecular patterns. Inflammasome assembly is nucleated by the oligomerisation of specific, activated pattern recognition receptors within the cytosol. Inflammasomes function as platforms for the activation of the caspase-1 protease, which in turn triggers the maturation and secretion of the pro inflammatory cytokines IL-1 beta and IL-18, and initiates pyroptosis, a highly inflammatory form of lytic cell death. Recently, additional inflammatory caspases (murine caspase-11, and human caspase-4/5) were also reported to be activated upon a pyroptosis-inducing 'non-canonical inflammasome' by direct recognition of lipopolysaccharide (LPS), a pathogen-associated molecular pattern. Here we review and discuss recent advances in our understanding of inflammasome-mediated host defence against Salmonella particularly in human cells, and their implications for cellular survival and cytokine secretion. (c) 2016 Elsevier Ltd. All rights reserved.
Formatted abstract
Inflammasomes are macromolecular complexes that assemble upon recognition of pathogen- or danger-associated molecular patterns. Inflammasome assembly is nucleated by the oligomerisation of specific, activated pattern recognition receptors within the cytosol. Inflammasomes function as platforms for the activation of the caspase-1 protease, which in turn triggers the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18, and initiates pyroptosis, a highly inflammatory form of lytic cell death. Recently, additional inflammatory caspases (murine caspase-11, and human caspase-4/5) were also reported to be activated upon a pyroptosis-inducing ‘non-canonical inflammasome’ by direct recognition of lipopolysaccharide (LPS), a pathogen-associated molecular pattern. Here we review and discuss recent advances in our understanding of inflammasome-mediated host defence against Salmonella particularly in human cells, and their implications for cellular survival and cytokine secretion.
Keyword Caspase
Inflammasome
NOD-like receptor
Salmonella
Toll-like receptor
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1064945
FT130100361
Institutional Status UQ
Additional Notes Published online 11 December 2016. Article in Press.Corrected proof.

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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