Fetal-maternal communication via extracellular vesicles - implications for complications of pregnancies

Adam, Stefanie, Elfeky, Omar, Kinhal, Vyjayanthi, Dutta, Suchismita, Lai, Andrew, Jayabalan, Nanthini, Nuzhat, Zarin, Palma, Carlos, Rice, Gregory E. and Salomon, Carlos (2016) Fetal-maternal communication via extracellular vesicles - implications for complications of pregnancies. Placenta, 54 83-88. doi:10.1016/j.placenta.2016.12.001


Author Adam, Stefanie
Elfeky, Omar
Kinhal, Vyjayanthi
Dutta, Suchismita
Lai, Andrew
Jayabalan, Nanthini
Nuzhat, Zarin
Palma, Carlos
Rice, Gregory E.
Salomon, Carlos
Title Fetal-maternal communication via extracellular vesicles - implications for complications of pregnancies
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
0143-4004
Publication date 2016-12-05
Sub-type Article (original research)
DOI 10.1016/j.placenta.2016.12.001
Open Access Status Not yet assessed
Volume 54
Start page 83
End page 88
Total pages 6
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2017
Language eng
Abstract The maternal physiology experiences numerous changes during pregnancy which are essential in controlling and maintaining maternal metabolic adaptations and fetal development. The human placenta is an organ that serves as the primary interface between the maternal and fetal circulation, thereby supplying the fetus with nutrients, blood and oxygen through the umbilical cord. During gestation, the placenta continuously releases several molecules into maternal circulation, including hormones, proteins, RNA and DNA. Interestingly, the presence of extracellular vesicles (EVs) of placental origin has been identified in maternal circulation across gestation. EVs can be categorised according to their size and/or origin into microvesicles (∼150-1000 nm) and exosomes (∼40-120 nm). Microvesicles are released by budding from the plasmatic membrane, whereas exosome release is by fusion of multivesicular bodies with the plasmatic membrane. Exosomes released from placental cells have been found to be regulated by oxygen tension and glucose concentration. Furthermore, maternal exosomes have the ability to stimulate cytokine release from endothelial cells. In this review, we will discuss the role of EVs during fetal-maternal communication during gestation with a special emphasis on exosomes.
Keyword Exosomes
Extracellular vesicles
Placenta
Pregnancy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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