Review: Eicosanoids in preterm labor and delivery: potential roles of exosomes in eicosanoid functions

Peiris, H. N., Vaswani, K., Almughlliq, F., Koh, Y. Q. and Mitchell, M. D. (2016) Review: Eicosanoids in preterm labor and delivery: potential roles of exosomes in eicosanoid functions. Placenta, 54 95-103. doi:10.1016/j.placenta.2016.12.013


Author Peiris, H. N.
Vaswani, K.
Almughlliq, F.
Koh, Y. Q.
Mitchell, M. D.
Title Review: Eicosanoids in preterm labor and delivery: potential roles of exosomes in eicosanoid functions
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
0143-4004
Publication date 2016-12-09
Sub-type Article (original research)
DOI 10.1016/j.placenta.2016.12.013
Open Access Status Not yet assessed
Volume 54
Start page 95
End page 103
Total pages 9
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2017
Language eng
Abstract Preterm delivery is a major obstetric health problem contributing to poor neonatal outcome including low birth weight, respiratory distress syndrome, gastrointestinal, immunologic, central nervous system, hearing, and vision problems. Worldwide, approximately 15 million babies are born prematurely each year. The critical question which remains is how to identify women destined to deliver preterm from those who will achieve a term delivery. Prostaglandins, in all mammals are important in the parturient process. Increased intrauterine prostaglandin production is associated with labor and in fact prostaglandin E2 (PGE2) or analogs are widely used clinically for cervical ripening and labor induction. Measurements of circulating eicosanoids have been problematic because of the rapid and major clearance by the lungs and then kidneys resulting in very low concentrations in plasma. Moreover, since eicosanoids are produced by all mammalian tissues, the sources of the measured eicosanoids are unknown. Our understanding of how cells communicate has undergone a paradigm shift with the recognition of the role of exosomes in intercellular signaling. Recent publications have identified enzymes and products of arachidonic acid metabolism (eicosanoids) within exosomes. This review will explore the potential roles of exosomes in eicosanoid functions that are critical in preterm labor and delivery.
Keyword Eicosanoids
Exosomes
Preterm birth
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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