The blood-brain barrier; protecting the developing fetal brain

Goasdoue, Kate, Miller, Stephanie M., Colditz, Paul B. and Bjorkman, S. Tracey (2017) The blood-brain barrier; protecting the developing fetal brain. Placenta, 54 111-116. doi:10.1016/j.placenta.2016.12.005

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Author Goasdoue, Kate
Miller, Stephanie M.
Colditz, Paul B.
Bjorkman, S. Tracey
Title The blood-brain barrier; protecting the developing fetal brain
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
Publication date 2017-06-01
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.placenta.2016.12.005
Open Access Status File (Author Post-print)
Volume 54
Start page 111
End page 116
Total pages 6
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Subject 2743 Reproductive Medicine
2729 Obstetrics and Gynaecology
1309 Developmental Biology
Abstract While placental function is fundamental to normal fetal development, the blood-brain barrier provides a second checkpoint critical to protecting the fetal brain and ensuring healthy brain development. The placenta is considered the key barrier between the mother and fetus, regulating delivery of essential nutrients, removing waste as well as protecting the fetus from potentially noxious substances. However, disturbances to the maternal environment and subsequent adaptations to placental function may render the placenta ineffective for providing a suitable environment for the developing fetus and to providing sufficient protection from harmful substances. The developing brain is particularly vulnerable to changes in the maternal/fetal environment. Development of the blood-brain barrier and maturation of barrier transporter systems work to protect the fetal brain from exposure to drugs, excluding them from the fetal CNS. This review will focus on the role of the 'other' key barrier during gestation - the blood-brain barrier - which has been shown to be functional as early as 8 weeks' gestation.
Keyword P-glycoprotein
Blood-brain barrier
Drug transporters
Fetal brain development
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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