Neuroinflammation in intrauterine growth restriction

Wixey, Julie A., Chand, Kirat K., Colditz, Paul B. and Bjorkman, S. Tracey (2017) Neuroinflammation in intrauterine growth restriction. Placenta, 54 117-124. doi:10.1016/j.placenta.2016.11.012

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Author Wixey, Julie A.
Chand, Kirat K.
Colditz, Paul B.
Bjorkman, S. Tracey
Title Neuroinflammation in intrauterine growth restriction
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
Publication date 2017-06-01
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.placenta.2016.11.012
Open Access Status File (Author Post-print)
Volume 54
Start page 117
End page 124
Total pages 8
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Subject 2743 Reproductive Medicine
2729 Obstetrics and Gynaecology
1309 Developmental Biology
Abstract Disruption to the maternal environment during pregnancy from events such as hypoxia, stress, toxins, inflammation, and reduced placental blood flow can affect fetal development. Intrauterine growth restriction (IUGR) is commonly caused by chronic placental insufficiency, interrupting supply of oxygen and nutrients to the fetus resulting in abnormal fetal growth. IUGR is a major cause of perinatal morbidity and mortality, occurring in approximately 5-10% of pregnancies. The fetal brain is particularly vulnerable in IUGR and there is an increased risk of long-term neurological disorders including cerebral palsy, epilepsy, learning difficulties, behavioural difficulties and psychiatric diagnoses. Few studies have focused on how growth restriction interferes with normal brain development in the IUGR neonate but recent studies in growth restricted animal models demonstrate increased neuroinflammation. This review describes the role of neuroinflammation in the progression of brain injury in growth restricted neonates. Identifying the mediators responsible for alterations in brain development in the IUGR infant is key to prevention and treatment of brain injury in these infants.
Keyword Growth retardation
Neonatal brain injury
Placental insufficiency
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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