Behavioural abnormalities of the hyposulphataemic Nas1 knock-out mouse

Dawson, Paul Anthony, Steane, Sarah Elizabeth and Markovich, Daniel (2004) Behavioural abnormalities of the hyposulphataemic Nas1 knock-out mouse. Behavioural Brain Research, 154 2: 457-463. doi:10.1016/j.bbr.2004.03.013

Author Dawson, Paul Anthony
Steane, Sarah Elizabeth
Markovich, Daniel
Title Behavioural abnormalities of the hyposulphataemic Nas1 knock-out mouse
Journal name Behavioural Brain Research   Check publisher's open access policy
ISSN 0166-4328
Publication date 2004-10-05
Sub-type Article (original research)
DOI 10.1016/j.bbr.2004.03.013
Open Access Status Not yet assessed
Volume 154
Issue 2
Start page 457
End page 463
Total pages 7
Place of publication Amsterdam
Publisher Elsevier B.V.
Language eng
Abstract We recently generated a sodium sulphate cotransporter knock-out mouse (Nas1-/-) which has increased urinary sulphate excretion and hyposulphataemia. To examine the consequences of disturbed sulphate homeostasis in the modulation of mouse behavioural characteristics, Nas1-/- mice were compared with Nas1+/- and Nas1+/+ littermates in a series of behavioural tests. The Nas1-/- mice displayed significantly (P < 0.001) decreased marble burying behaviour (4.33 +/- 0.82 buried) when compared to Nas1+/+ (7.86 +/- 0.44) and Nas1+/- (8.40 +/- 0.37) animals, suggesting that Nas1-/- mice may have decreased object-induced anxiety. The Nas1-/- mice also displayed decreased locomotor activity by moving less distance (1.53 +/- 0.27 m, P < 0.05) in an open-field test when compared to Nas1+/+ (2.31 +/- 0.24 m) and Nas1+/- (2.15 +/- 0.19 m) mice. The three genotypes displayed similar spatiotemporal and ethological behaviours in the elevated-plus maze and open-field test, with the exception of a decreased defecation frequency by the Nas1-/- mice (40% reduction, P < 0.01). There were no significant differences between Nas1-/- and Nas1+/+ mice in a rotarod performance test of motor coordination and in the forced swim test assessing (anti-)depressant-like behaviours. This is the first study to demonstrate behavioural abnormalities in the hyposulphataemic Nas1-/- mice. (C) 2004 Elsevier B.V. All rights reserved.
Keyword Behavioral Sciences
Marble Bury
Marble-burying Behavior
Elevated Plus-maze
Inorganic Sulfate
Xenobiotic Metabolism
Mice Lacking
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 26 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 14 Aug 2007, 00:38:38 EST