Bio-compartmentalization of microRNAs in exosomes during gestational diabetes mellitus

Iljas, Juvita D., Guanzon, Dominic, Elfeky, Omar, Rice, Gregory E. and Salomon, Carlos (2017) Bio-compartmentalization of microRNAs in exosomes during gestational diabetes mellitus. Placenta, 54 76-82. doi:10.1016/j.placenta.2016.12.002

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Author Iljas, Juvita D.
Guanzon, Dominic
Elfeky, Omar
Rice, Gregory E.
Salomon, Carlos
Title Bio-compartmentalization of microRNAs in exosomes during gestational diabetes mellitus
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
Publication date 2017-06-01
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.placenta.2016.12.002
Open Access Status File (Author Post-print)
Volume 54
Start page 76
End page 82
Total pages 7
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Abstract Analysis of the human genome revealed that only 1.2% encoded for proteins, which raised questions regarding the biological significance of the remaining genome. We now know that approximately 80% of the genome serves at least one biochemical function within the cell. A portion of this 80% consists of a family of non-coding regulatory RNAs, one important member being microRNAs (miRNAs). miRNAs can be detected in tissues and biofluids, where miRNAs in the latter can be bound to proteins or encapsulated within lipid vesicles such as exosomes. Gestational diabetes mellitus (GDM) is a complication of pregnancy, which has harmful health impacts on both the fetus as well as the mother. The incidence of GDM worldwide varies, but reached 18% in the HAPO cohort using the new International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Not only has GDM been associated with increased risks of further complications during pregnancy, but also pose long-term risks for both the mother and the baby. Thus, understanding the pathophysiology of GDM is important from a public health perspective. Literature has demonstrated that GDM is associated with elevated levels of circulating exosomes in maternal circulation. However, there is a paucity of data defining the expression, role, and diagnostic utility of miRNAs in GDM. This review briefly summarizes recent advances in the function and quantification of intracellular and extracellular miRNAs in GDM.
Keyword Biomarkers
Extracellular vesicles
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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