Streptococcal immunity is constrained by lack of immunological memory following a single episode of pyoderma

Pandey, Manisha, Ozberk, Victoria, Calcutt, Ainslie, Langshaw, Emma, Powell, Jessica, Rivera-Hernandez, Tania, Ho, Mei-Fong, Philips, Zachary, Batzloff, Michael R. and Good, Michael F. (2016) Streptococcal immunity is constrained by lack of immunological memory following a single episode of pyoderma. PLoS Pathogens, 12 12: e1006122. doi:10.1371/journal.ppat.1006122


Author Pandey, Manisha
Ozberk, Victoria
Calcutt, Ainslie
Langshaw, Emma
Powell, Jessica
Rivera-Hernandez, Tania
Ho, Mei-Fong
Philips, Zachary
Batzloff, Michael R.
Good, Michael F.
Title Streptococcal immunity is constrained by lack of immunological memory following a single episode of pyoderma
Journal name PLoS Pathogens   Check publisher's open access policy
ISSN 1553-7374
1553-7366
Publication date 2016-12-27
Sub-type Article (original research)
DOI 10.1371/journal.ppat.1006122
Open Access Status DOI
Volume 12
Issue 12
Start page e1006122
Total pages 19
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Subject 2405 Parasitology
2404 Microbiology
2403 Immunology
1312 Molecular Biology
1311 Genetics
2406 Virology
Abstract The immunobiology underlying the slow acquisition of skin immunity to group A streptococci (GAS), is not understood, but attributed to specific virulence factors impeding innate immunity and significant antigenic diversity of the type-specific M-protein, hindering acquired immunity. We used a number of epidemiologically distinct GAS strains to model the development of acquired immunity. We show that infection leads to antibody responses to the serotype-specific determinants on the M-protein and profound protective immunity; however, memory B cells do not develop and immunity is rapidly lost. Furthermore, antibodies do not develop to a conserved M-protein epitope that is able to induce immunity following vaccination. However, if re-infected with the same strain within three weeks, enduring immunity and memory B-cells (MBCs) to type-specific epitopes do develop. Such MBCs can adoptively transfer protection to naïve recipients. Thus, highly protective M-protein-specific MBCs may never develop following a single episode of pyoderma, contributing to the slow acquisition of immunity and to streptococcal endemicity in at-risk populations.
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID APP1037304
APP1044023
APP1083548
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
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