Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

Klyne, David M., Barbe, Mary F. and Hodges, Paul W. (2017) Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain. Brain, Behavior, and Immunity, 60 84-92. doi:10.1016/j.bbi.2016.10.003

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Author Klyne, David M.
Barbe, Mary F.
Hodges, Paul W.
Title Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain
Journal name Brain, Behavior, and Immunity   Check publisher's open access policy
ISSN 1090-2139
0889-1591
Publication date 2017-02-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.bbi.2016.10.003
Open Access Status File (Author Post-print)
Volume 60
Start page 84
End page 92
Total pages 9
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2018
Language eng
Abstract Systemic inflammation is linked with development and persistence of many pathological pain states. Although chronic phase inflammatory responses are well reported, the acute phase has received limited attention. Here we investigated circulating pro-inflammatory cytokines and C-reactive protein (CRP), and explored their relationships with symptom severity and other factors in acute low back pain (LBP). Ninety-nine individuals within two weeks of onset of acute LBP and 55 pain-free controls completed questionnaires related to their pain (visual analogue scale, VAS) and disability, behaviour, sleep quality and psychological status. CRP, interleukin-6 (IL-6), tumor necrosis factor (TNF) and interleukin-1β (IL-1β) were measured from serum samples. Biomarkers were compared between LBP and control participants, and in a separate analysis, for those with “high-pain” (VAS ⩾4) and “low-pain” (VAS <4). The relationships between biomarkers and all other variables, including other cytokines/CRP were assessed. CRP was higher in LBP than controls and in those with high- than low-pain (p < 0.01). IL-6 was higher in those with high- than low-pain (p < 0.05), but not controls. Various pain and non-pain factors were associated with each biomarker differently. These findings suggest systemic CRP and IL-6 are important contributors to inflammation in the early post-onset phase of LBP and that various factors can shape these responses.
Keyword C-reactive protein (CRP)
Interleukin-1β (IL-1β)
Interleukin-6 (IL-6)
Low back pain (LBP)
Pro-inflammatory cytokines
Tumor necrosis factor (TNF)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Health and Rehabilitation Sciences Publications
 
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