Cancer therapeutics with epigallocatechin-3-gallate encapsulated in biopolymeric nanoparticles

Tyagi, Nisha, De, Ranjit, Begun, Jakob and Popat, Amirali (2017) Cancer therapeutics with epigallocatechin-3-gallate encapsulated in biopolymeric nanoparticles. International Journal of Pharmaceutics, 518 1-2: 220-227. doi:10.1016/j.ijpharm.2016.12.030

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Author Tyagi, Nisha
De, Ranjit
Begun, Jakob
Popat, Amirali
Title Cancer therapeutics with epigallocatechin-3-gallate encapsulated in biopolymeric nanoparticles
Journal name International Journal of Pharmaceutics   Check publisher's open access policy
ISSN 1873-3476
0378-5173
Publication date 2017-02-25
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.ijpharm.2016.12.030
Open Access Status File (Author Post-print)
Volume 518
Issue 1-2
Start page 220
End page 227
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Abstract With the recent quantum leap in chemoprevention by dietary products, their use as cancer therapeutics is garnering worldwide attention. The concept of effortlessly fighting this deadly disease by gulping cups of green tea or swallowing green tea extract capsules is appreciated universally. Epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, has generated significant interest in controlling carcinogenesis due to its growth-inhibitory efficacy against a variety of cancers by targeting multiple signaling pathways. However, the success of EGCG in preclinical studies is difficult to translate into clinical trials due to issues of low solubility, bioavailability and an uncertain therapeutic window. The laborious and expensive journey of drugs from the laboratory to commercialization can be improved by utilizing nanoparticles as anti-cancer drug carriers. Exploitation of biopolymeric nanoparticles in recent years has improved EGCG's biodistribution, stability and tumor selectivity, revealing its superior chemopreventive effects. This review briefly summarizes recent developments regarding the targets and side effects of EGCG, complications associated with its low bioavailability and critically analyses the application of biopolymeric nanoparticles encapsulating EGCG as a next generation delivery systems.
Keyword Biopolymers
Cancer
EGCG
Green tea
Nanoparticles
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
HERDC Pre-Audit
School of Pharmacy Publications
School of Clinical Medicine Publications
Admin Only - School of Clinical Medicine
 
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