The role of infarct transmural extent in infarct extension: a computational study

Leong Chin-Neng, Lim, Einly, Andriyana, Andri, Al Abed, Amr, Lovell, Nigel Hamilton, Hayward, Christopher, Hamilton-Craig, Christian and Dokos, Socrates (2017) The role of infarct transmural extent in infarct extension: a computational study. International Journal for Numerical Methods in Biomedical Engineering, 33 2: e02794.1-e02794.18. doi:10.1002/cnm.2794

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Author Leong Chin-Neng
Lim, Einly
Andriyana, Andri
Al Abed, Amr
Lovell, Nigel Hamilton
Hayward, Christopher
Hamilton-Craig, Christian
Dokos, Socrates
Title The role of infarct transmural extent in infarct extension: a computational study
Journal name International Journal for Numerical Methods in Biomedical Engineering   Check publisher's open access policy
ISSN 2040-7947
Publication date 2017-02-01
Sub-type Article (original research)
DOI 10.1002/cnm.2794
Open Access Status File (Author Post-print)
Volume 33
Issue 2
Start page e02794.1
End page e02794.18
Total pages 18
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Language eng
Subject 2204 Religion and Religious Studies
1312 Molecular Biology
1703 Computational Theory and Mathematics
1712 Software
2604 Applied Mathematics
2611 Modelling and Simulation
Abstract Infarct extension, a process involving progressive extension of the infarct zone (IZ) into the normally perfused border zone (BZ), leads to continuous degradation of the myocardial function and adverse remodelling. Despite carrying a high risk of mortality, detailed understanding of the mechanisms leading to BZ hypoxia and infarct extension remains unexplored. In the present study, we developed a 3D truncated ellipsoidal left ventricular model incorporating realistic electromechanical properties and fibre orientation to examine the mechanical interaction among the remote, infarct and BZs in the presence of varying infarct transmural extent (TME). Localized highly abnormal systolic fibre stress was observed at the BZ, owing to the simultaneous presence of moderately increased stiffness and fibre strain at this region, caused by the mechanical tethering effect imposed by the overstretched IZ. Our simulations also demonstrated the greatest tethering effect and stress in BZ regions with fibre direction tangential to the BZ–remote zone boundary. This can be explained by the lower stiffness in the cross-fibre direction, which gave rise to a greater stretching of the IZ in this direction. The average fibre strain of the IZ, as well as the maximum stress in the sub-endocardial layer, increased steeply from 10% to 50% infarct TME, and slower thereafter. Based on our stress–strain loop analysis, we found impairment in the myocardial energy efficiency and elevated energy expenditure with increasing infarct TME, which we believe to place the BZ at further risk of hypoxia.
Keyword Border zone
Finite element modelling
Infarct extension
Infarct transmural extent
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Mon, 16 Jan 2017, 22:44:43 EST by Anthony Yeates on behalf of Learning and Research Services (UQ Library)