An atypical role for the myeloid receptor Mincle in central nervous system injury

Arumugam, Thiruma V., Manzanero, Silvia, Furtado, Milena, Biggins, Patrick J., Hsieh, Yu Hsuan, Gelderblom, Mathias, MacDonald, Kelli P. A., Salimova, Ekaterina, Li, Yu I., Korn, Othmar, Dewar, Deborah, Macrae, I. Mhairi, Ashman, Robert B., Tang, Sung-Chun, Rosenthal, Nadia A., Ruitenberg, Marc J., Magnus, Tim and Wells, Christine A. (2016) An atypical role for the myeloid receptor Mincle in central nervous system injury. Journal of Cerebral Blood Flow and Metabolism, 37 6: 2098-2111. doi:10.1177/0271678X16661201

Author Arumugam, Thiruma V.
Manzanero, Silvia
Furtado, Milena
Biggins, Patrick J.
Hsieh, Yu Hsuan
Gelderblom, Mathias
MacDonald, Kelli P. A.
Salimova, Ekaterina
Li, Yu I.
Korn, Othmar
Dewar, Deborah
Macrae, I. Mhairi
Ashman, Robert B.
Tang, Sung-Chun
Rosenthal, Nadia A.
Ruitenberg, Marc J.
Magnus, Tim
Wells, Christine A.
Title An atypical role for the myeloid receptor Mincle in central nervous system injury
Journal name Journal of Cerebral Blood Flow and Metabolism   Check publisher's open access policy
ISSN 0271-678X
Publication date 2016-08-19
Year available 2016
Sub-type Article (original research)
DOI 10.1177/0271678X16661201
Open Access Status Not yet assessed
Volume 37
Issue 6
Start page 2098
End page 2111
Total pages 14
Place of publication London, United Kingdom
Publisher Sage Publications
Language eng
Subject 2808 Neurology
2728 Clinical Neurology
2705 Cardiology and Cardiovascular Medicine
Abstract The C-type lectin Mincle is implicated in innate immune responses to sterile inflammation, but its contribution to associated pathologies is not well understood. Herein, we show that Mincle exacerbates neuronal loss following ischemic but not traumatic spinal cord injury. Loss of Mincle was beneficial in a model of transient middle cerebral artery occlusion but did not alter outcomes following heart or gut ischemia. High functional scores in Mincle KO animals using the focal cerebral ischemia model were accompanied by reduced lesion size, fewer infiltrating leukocytes and less neutrophil-derived cytokine production than isogenic controls. Bone marrow chimera experiments revealed that the presence of Mincle in the central nervous system, rather than recruited immune cells, was the critical regulator of a poor outcome following transient middle cerebral artery occlusion. There was no evidence for a direct role for Mincle in microglia or neural activation, but expression in a subset of macrophages resident in the perivascular niche provided new clues on Mincle's role in ischemic stroke.
Keyword C-type lectin
Middle cerebral artery occlusion
Sterile inflammation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Sat, 14 Jan 2017, 02:32:41 EST by Kirstie Asmussen on behalf of School of Music