An extended filament based lamellipodium model produces various moving cell shapes in the presence of chemotactic signals

Manhart, Angelika, Oelz, Dietmar, Schmeiser, Christian and Sfakianakis, Nikolaos (2015) An extended filament based lamellipodium model produces various moving cell shapes in the presence of chemotactic signals. Journal of Theoretical Biology, 382 244-258. doi:10.1016/j.jtbi.2015.06.044


Author Manhart, Angelika
Oelz, Dietmar
Schmeiser, Christian
Sfakianakis, Nikolaos
Title An extended filament based lamellipodium model produces various moving cell shapes in the presence of chemotactic signals
Journal name Journal of Theoretical Biology   Check publisher's open access policy
ISSN 0022-5193
1095-8541
Publication date 2015-10-07
Sub-type Article (original research)
DOI 10.1016/j.jtbi.2015.06.044
Open Access Status Not yet assessed
Volume 382
Start page 244
End page 258
Total pages 15
Place of publication London, United Kingdom
Publisher Academic Press
Language eng
Abstract The Filament Based Lamellipodium Model (FBLM) is a two-phase two-dimensional continuum model, describing the dynamics of two interacting families of locally parallel actin filaments (Oelz and Schmeiser, 2010b). It contains accounts of the filaments[U+05F3] bending stiffness, of adhesion to the substrate, and of cross-links connecting the two families.An extension of the model is presented with contributions from nucleation of filaments by branching, from capping, from contraction by actin-myosin interaction, and from a pressure-like repulsion between parallel filaments due to Coulomb interaction. The effect of a chemoattractant is described by a simple signal transduction model influencing the polymerization speed. Simulations with the extended model show its potential for describing various moving cell shapes, depending on the signal transduction procedure, and for predicting transients between non-moving and moving states as well as changes of direction.
Keyword Chemotaxis
Actin
Mathematical model
Cytoskeleton
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Mathematics and Physics
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 14 Jan 2017, 01:49:37 EST by Kay Mackie on behalf of School of Mathematics & Physics