Hypothalamic obesity following craniopharyngioma surgery: results of a pilot trial of combined metformin and diazoxide therapy

Hamilton, Jill K., Conwell, Louise S., Syme, Catriona, Ahmet, Alexandra, Jefferies, Allison and Daneman, Denis (2011) Hypothalamic obesity following craniopharyngioma surgery: results of a pilot trial of combined metformin and diazoxide therapy. International Journal of Pediatric Endocrinology, 2011 . doi:10.1155/2011/417949


Author Hamilton, Jill K.
Conwell, Louise S.
Syme, Catriona
Ahmet, Alexandra
Jefferies, Allison
Daneman, Denis
Title Hypothalamic obesity following craniopharyngioma surgery: results of a pilot trial of combined metformin and diazoxide therapy
Journal name International Journal of Pediatric Endocrinology
ISSN 1687-9848
1687-9856
Publication date 2011-03-01
Sub-type Article (original research)
DOI 10.1155/2011/417949
Open Access Status DOI
Volume 2011
Total pages 7
Place of publication London, United Kingdom
Publisher BioMed Central
Formatted abstract
Objective: To assess the effect of combined diazoxide-metformin therapy in obese adolescents treated for craniopharyngioma.

Design: A prospective open-label 6-month pilot treatment trial in 9 obese subjects with craniopharyngioma. Diazoxide (2 mg/kg
divided b.i.d., maximum 200 mg/day) and metformin (1000 mg b.i.d.). Whole body insulin sensitivity index (WBISI) and area under-the-curve insulin (AUCins) were calculated.

Results: Seven subjects completed: 4M/3F, mean ± SD age 15.4 ± 2.9 years, weight 99.7 ± 26.3 kg, BMI 35.5 ± 5.6 kg/m2, and BMI SDS 2.3 ± 0.3. Two were withdrawn due to vomiting and peripheral edema. Of participants completing the study, the mean ± SD weight gain, BMI, and BMI SDS during the 6 months were reduced compared to the 6 months prestudy (+1.2 ± 5.9 versus +9.5 ± 2.7 kg, P = .004; −0.3 ± 2.3 versus +2.2 ± 1.5 kg/m2, P = .04; −0.04 ± 0.15 versus +0.11 ± 0.08, P = .021, resp.). AUCins correlated with weight loss (r = 0.82, P = .02) and BMI decrease (r = 0.96, P = .009).

Conclusion: Combined diazoxide-metformin therapy was associated with reduced weight gain in patients with hypothalamic obesity. AUCins at study commencement predicted effectiveness of the treatment.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Fri, 13 Jan 2017, 15:27:03 EST by Dr Louise Conwell on behalf of Mater Clinical Unit