A combination of actin treadmilling and cross-linking drives contraction of random actomyosin arrays

Oelz, Dietmar B., Rubinstein, Boris Y. and Mogilner, Alex (2015) A combination of actin treadmilling and cross-linking drives contraction of random actomyosin arrays. Biophysical Journal, 109 9: 1818-1829. doi:10.1016/j.bpj.2015.09.013


Author Oelz, Dietmar B.
Rubinstein, Boris Y.
Mogilner, Alex
Title A combination of actin treadmilling and cross-linking drives contraction of random actomyosin arrays
Journal name Biophysical Journal   Check publisher's open access policy
ISSN 0006-3495
1542-0086
Publication date 2015-11-03
Sub-type Article (original research)
DOI 10.1016/j.bpj.2015.09.013
Open Access Status Not yet assessed
Volume 109
Issue 9
Start page 1818
End page 1829
Total pages 12
Place of publication St. Louis, MO, United States
Publisher Cell Press
Language eng
Abstract We investigate computationally the self-organization and contraction of an initially random actomyosin ring. In the framework of a detailed physical model for a ring of cross-linked actin filaments and myosin-II clusters, we derive the force balance equations and solve them numerically. We find that to contract, actin filaments have to treadmill and to be sufficiently cross linked, and myosin has to be processive. The simulations reveal how contraction scales with mechanochemical parameters. For example, they show that the ring made of longer filaments generates greater force but contracts slower. The model predicts that the ring contracts with a constant rate proportional to the initial ring radius if either myosin is released from the ring during contraction and actin filaments shorten, or if myosin is retained in the ring, while the actin filament number decreases. We demonstrate that a balance of actin nucleation and compression-dependent disassembly can also sustain contraction. Finally, the model demonstrates that with time pattern formation takes place in the ring, worsening the contractile process. The more random the actin dynamics are, the higher the contractility will be.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Mathematics and Physics
 
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Created: Fri, 13 Jan 2017, 22:44:26 EST by Kay Mackie on behalf of School of Mathematics & Physics