Actomyosin contraction, aggregation and traveling waves in a treadmilling actin array

Oelz, Dietmar and Mogilner, Alex (2016) Actomyosin contraction, aggregation and traveling waves in a treadmilling actin array. Physica D: Nonlinear Phenomena, 318-319 70-83. doi:10.1016/j.physd.2015.10.005


Author Oelz, Dietmar
Mogilner, Alex
Title Actomyosin contraction, aggregation and traveling waves in a treadmilling actin array
Journal name Physica D: Nonlinear Phenomena   Check publisher's open access policy
ISSN 0167-2789
1872-8022
Publication date 2016-04-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.physd.2015.10.005
Open Access Status Not yet assessed
Volume 318-319
Start page 70
End page 83
Total pages 14
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
We use perturbation theory to derive a continuum model for the dynamic actomyosin bundle/ring in the regime of very strong crosslinking. Actin treadmilling is essential for contraction. Linear stability analysis and numerical solutions of the model equations reveal that when the actin treadmilling is very slow, actin and myosin aggregate into equidistantly spaced peaks. When treadmilling is significant, actin filament of one polarity are distributed evenly, while filaments of the opposite polarity develop a shock wave moving with the treadmilling velocity. Myosin aggregates into a sharp peak surfing the crest of the actin wave. Any actomyosin aggregation diminishes contractile stress. The easiest way to maintain higher contraction is to upregulate the actomyosin turnover which destabilizes nontrivial patterns and stabilizes the homogeneous actomyosin distributions. We discuss the model’s implications for the experiment.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
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Created: Fri, 13 Jan 2017, 22:37:19 EST by Kay Mackie on behalf of School of Mathematics & Physics