Home monitoring of fasting and postprandial triglycerides in late pregnancy: a pilot study

Barrett, Helen L., McIntyre, H. David, D'Emden, Michael, Dekker Nitert, Marloes and Callaway, Leonie K. (2017) Home monitoring of fasting and postprandial triglycerides in late pregnancy: a pilot study. Diabetes Care, 40 1: e1-e2. doi:10.2337/dc16-2181


Author Barrett, Helen L.
McIntyre, H. David
D'Emden, Michael
Dekker Nitert, Marloes
Callaway, Leonie K.
Title Home monitoring of fasting and postprandial triglycerides in late pregnancy: a pilot study
Journal name Diabetes Care   Check publisher's open access policy
ISSN 1935-5548
0149-5992
Publication date 2017-01-01
Year available 2017
Sub-type Article (original research)
DOI 10.2337/dc16-2181
Open Access Status Not yet assessed
Volume 40
Issue 1
Start page e1
End page e2
Total pages 2
Place of publication Alexandria, United States
Publisher American Diabetes Association
Language eng
Formatted abstract
Elevated maternal triglycerides are associated with adverse pregnancy outcomes (1). In pregnancy, triglycerides are measured infrequently and mostly fasting, leading to a lack of data on the variability and flux of triglycerides (1). This study explored capillary triglyceride concentrations in late pregnancy using a validated Roche Accutrend triglyceride meter (2).

This was a prospective observational cohort study that was approved by the local human research ethics committee. For 6 days, women monitored fasting and 2-h postprandial capillary glucose and triglyceride levels. Results are mean millimoles per liter with SD unless otherwise indicated. Women reported on the usability of the meter.

Twelve women enrolled at mean 258 (9) [mean (SD)] days’ gestation. Eight women (66%) had gestational diabetes mellitus, of whom four were prescribed insulin and one metformin. Mean (SD) fasting glucose levels were lower than postprandial glucose levels [4.67 (0.44) vs. 6.06 (1.11) mmol/L, P < 0.001]. Mean fasting and mean postprandial glucose levels for each participant were correlated (Pearson’s r 0.67, P = 0.02, n = 12) (Fig. 1A). Mean fasting and postprandial triglycerides were not significantly different [3.20 (1.13) vs. 3.45 (1.21), P = 0.19] and were correlated (Pearson’s r 0.64, P = 0.03, n = 11) (Fig. 1B). Glucose and triglyceride concentrations showed no significant correlation either in the fasting or postprandial state (Fig. 1C and D). The across-day glucose (Fig. 1E) and triglyceride (Fig. 1F) levels show within- and between-person variability.
Keyword Endocrinology & Metabolism
Endocrinology & Metabolism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Fri, 13 Jan 2017, 20:44:30 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences