Bacterial cellulose: long-term biocompatibility studies

Pertile, Renata A. N., Moreira, Susana, Gil da Costa, Rui M., Correia, Alexandra, Guardao, Luisa, Gartner, Fatima, Vilanova, Manuel and Gama, Miguel (2012) Bacterial cellulose: long-term biocompatibility studies. Journal of Biomaterials Science, Polymer Edition, 23 10: 1339-1354. doi:10.1163/092050611X581516

Author Pertile, Renata A. N.
Moreira, Susana
Gil da Costa, Rui M.
Correia, Alexandra
Guardao, Luisa
Gartner, Fatima
Vilanova, Manuel
Gama, Miguel
Title Bacterial cellulose: long-term biocompatibility studies
Journal name Journal of Biomaterials Science, Polymer Edition   Check publisher's open access policy
ISSN 0920-5063
Publication date 2012-01-01
Sub-type Article (original research)
DOI 10.1163/092050611X581516
Open Access Status Not yet assessed
Volume 23
Issue 10
Start page 1339
End page 1354
Total pages 16
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Language eng
Formatted abstract
The bacterial cellulose (BC) secreted by Gluconacetobacter xylinus is a network of pure cellulose nanofibres which has high crystallinity, wettability and mechanical strength. These characteristics make BC an excellent material for tissue-engineering constructs, noteworthy for artificial vascular grafts. In this work, the in vivo biocompatibility of BC membranes produced by two G. xylinus strains was analyzed through histolog-ical analysis of long-term subcutaneous implants in the mice. The BC implants caused a mild and benign inflammatory reaction that decreased along time and did not elicit a foreign body reaction. A tendency to calcify over time, which may be related to the porosity of the BC implants, was observed, especially among the less porous BC-1 implants. In addition, the potential toxicity of BC nanofibres - obtained by chemical-mechanical treatment of BC membranes - subcutaneously implanted in mice was analysed through bone marrow flow cytometry and histological analyses. At 2 and 4 months post-implantation, the nanofibres implants were found to accumulate intracellularly, in subcutaneous foamy macrophages aggregates. Moreover, no differences were observed between the controls and implanted animals in thymocyte populations and in B lymphocyte precursors and myeloid cells in the bone marrow.
Keyword Bacterial cellulose
In vivo biocompatibility
Tissue engineering
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 12 Jan 2017, 00:44:30 EST by Renata Aparecida Nedel Pertile on behalf of Learning and Research Services (UQ Library)