Complement in the fundamental processes of the cell

Hawksworth, Owen A., Coulthard, Liam G. and Woodruff, Trent M. (2016) Complement in the fundamental processes of the cell. Molecular Immunology, 84 17-25. doi:10.1016/j.molimm.2016.11.010


Author Hawksworth, Owen A.
Coulthard, Liam G.
Woodruff, Trent M.
Title Complement in the fundamental processes of the cell
Journal name Molecular Immunology   Check publisher's open access policy
ISSN 1872-9142
0161-5890
Publication date 2016-11-25
Sub-type Article (original research)
DOI 10.1016/j.molimm.2016.11.010
Open Access Status Not yet assessed
Volume 84
Start page 17
End page 25
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Abstract Once regarded solely as an activator of innate immunity, it is now clear that the complement system acts in an assortment of cells and tissues, with immunity only one facet of a diverse array of functions under the influence of the complement proteins. Throughout development, complement activity has now been demonstrated from early sperm-egg interactions in fertilisation, to regulation of epiboly and organogenesis, and later in refinement of cerebral synapses. Complement has also been shown to regulate homeostasis of adult tissues, controlling cell processes such as migration, survival, repair, and regeneration. Given the continuing emergence of such novel actions of complement, the existing research likely represents only a fraction of the myriad of functions of this complex family of proteins. This review is focussed on outlining the current knowledge of complement family members in the regulation of cell processes in non-immune systems. It is hoped this will spur research directed towards revealing more about the role of complement in these fundamental cell processes.
Keyword Complement
Development
Homeostasis
Migration
Pruning
Regeneration
Survival
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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