Cellular players of hematopoietic stem cell mobilization in the bone marrow niche

Tay, Joshua, Levesque, Jean‑Pierre and Winkler, Ingrid G. (2016) Cellular players of hematopoietic stem cell mobilization in the bone marrow niche. International Journal of Hematology, 105 2: 1-12. doi:10.1007/s12185-016-2162-4


Author Tay, Joshua
Levesque, Jean‑Pierre
Winkler, Ingrid G.
Title Cellular players of hematopoietic stem cell mobilization in the bone marrow niche
Journal name International Journal of Hematology   Check publisher's open access policy
ISSN 1865-3774
0925-5710
Publication date 2016-12-10
Year available 2017
Sub-type Article (original research)
DOI 10.1007/s12185-016-2162-4
Open Access Status Not yet assessed
Volume 105
Issue 2
Start page 1
End page 12
Total pages 12
Place of publication Tokyo, Japan
Publisher Springer Japan
Language eng
Abstract Hematopoietic stem cells (HSC) reside in perivascular regions of the bone marrow (BM) embedded within a complex regulatory unit called the niche. Cellular components of HSC niches include vascular endothelial cells, mesenchymal stromal progenitor cells and a variety of mature hematopoietic cells such as macrophages, neutrophils, and megakaryocytes—further regulated by sympathetic nerves and complement components as described in this review. Three decades ago the discovery that cytokines induce a large number of HSC to mobilize from the BM into the blood where they are easily harvested, revolutionised the field of HSC transplantation—curative for immune-deficiencies and some malignancies. However, despite now routine use of granulocyte-colony stimulating factor (G-CSF) to mobilise HSC for transplant, only in last 15 years has research on the mechanisms behind why and how HSC can be induced to move into the blood began. These studies have revealed the complexity of the niche that retains HSC in the BM. This review describes how BM niches and HSC themselves change during administration of G-CSF—or in the recovery phase of chemotherapy—to facilitate movement of HSC into the blood, and research now leading to development of novel therapeutics to further boost HSC mobilization and transplant success.
Keyword Bone marrow
Hematopoietic stem cells
Mobilization
Stem cell niche
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1044091
1046590
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
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