NaV1.7 as a pain target – from gene to pharmacology

Vetter, Irina, Deuis, Jennifer, Mueller, Alexander, Israel, Mathilde R., Hana Starobova, Zhang, Alan, Rash, Lachlan D. and Mobli, Mehdi (2016) NaV1.7 as a pain target – from gene to pharmacology. Pharmacology and Therapeutics, 172 73-100. doi:10.1016/j.pharmthera.2016.11.015

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Author Vetter, Irina
Deuis, Jennifer
Mueller, Alexander
Israel, Mathilde R.
Hana Starobova
Zhang, Alan
Rash, Lachlan D.
Mobli, Mehdi
Title NaV1.7 as a pain target – from gene to pharmacology
Formatted title
NaV1.7 as a pain target – from gene to pharmacology
Journal name Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 0163-7258
1879-016X
Publication date 2016-12-02
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.pharmthera.2016.11.015
Open Access Status File (Author Post-print)
Volume 172
Start page 73
End page 100
Total pages 28
Place of publication Philadelphia, PA United States
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
NaV1.7, a subtype of the voltage-gated sodium channel family that is highly expressed in peripheral sensory neurons, remains one of the most promising targets for the treatment of pain. However, despite compelling genetic evidence supporting a key role for NaV1.7 in regulating excitability of peripheral sensory neurons, the development of truly subtype-selective inhibitors has been challenging. Here, we discuss complexities surrounding targeting NaV1.7 pharmacologically for treatment of pain and explore future opportunities for development of effective analgesic NaV1.7 inhibitors.
Keyword Sodium channel
Pain
Sensory neuron
Congenital insensitivity to pain
Inherited erythromelalgia
Paroxysmal extreme pain disorder
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Mon, 09 Jan 2017, 21:27:01 EST by Susan Allen on behalf of Institute for Molecular Bioscience