Therapeutic implications of epigenetic signaling in breast cancer

Oh, Tae Gyu, Wang, Shu-Ching M. and Muscat, George E. O. (2017) Therapeutic implications of epigenetic signaling in breast cancer. Endocrinology, 158 3: 431-447. doi:10.1210/en.2016-1716#sthash.yDPl6B8Z.dpuf

Author Oh, Tae Gyu
Wang, Shu-Ching M.
Muscat, George E. O.
Title Therapeutic implications of epigenetic signaling in breast cancer
Journal name Endocrinology   Check publisher's open access policy
ISSN 0013-7227
Publication date 2017-03-01
Sub-type Article (original research)
DOI 10.1210/en.2016-1716#sthash.yDPl6B8Z.dpuf
Open Access Status Not yet assessed
Volume 158
Issue 3
Start page 431
End page 447
Total pages 17
Place of publication Cary, NC, United States
Publisher Oxford University Press
Language eng
Abstract Breast cancer is a heterogeneous disease and its complexity has hindered the development of efficacious treatments targeting all breast cancer subtypes. Many studies have linked the diversity of breast carcinogenesis and metastasis to aberrant epigenetic signaling and control. Here, we focus on the current state of the discipline and review the major epigenetic enzymes controlling chromatin structure and function in the context of breast cancer, including i) DNA methyltransferases, ii) lysine methyltransferases and demethylases, iii) protein arginine methyltransferases, iv) histone acetyltransferases and deacetylases. Moreover, therapeutic drugs targeting these epigenetic enzymes are rapidly emerging and/or undergoing clinical trials. Therefore, we discuss the pharmacological manipulation of epigenetic enzymes for breast cancer treatment, and present new clinical and survival outcome analysis on epigenetic factors that have evaded analysis to date. Understanding and pharmacologically exploiting epigenetic regulation in breast cancer promises to be an essential aspect of next generation drug development and adjuvant therapies targeting advanced disease and treatment resistant tumors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published Online 16 December 2016. Accepted manuscript. Article in Press

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
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Created: Mon, 09 Jan 2017, 21:14:54 EST by Susan Allen on behalf of Institute for Molecular Bioscience