Tailoring biomaterial scaffolds for osteochondral repair

Camarero-Espinosa, Sandra and Cooper-White, Justin (2017) Tailoring biomaterial scaffolds for osteochondral repair. International Journal of Pharmaceutics, 523 2: 476-489. doi:10.1016/j.ijpharm.2016.10.035

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Author Camarero-Espinosa, Sandra
Cooper-White, Justin
Title Tailoring biomaterial scaffolds for osteochondral repair
Journal name International Journal of Pharmaceutics   Check publisher's open access policy
ISSN 1873-3476
Publication date 2017-05-25
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.ijpharm.2016.10.035
Open Access Status File (Author Post-print)
Volume 523
Issue 2
Start page 476
End page 489
Total pages 14
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 3003 Pharmaceutical Science
Abstract Articular cartilage is a mechanically and structurally complex, lubricious tissue that permits load-bearing and frictionless movement of our joints upon articulation. Unfortunately, cartilage is unable to properly self-heal as a result of acute trauma or damage, resulting in many cases in significant pain, reduction in physical activity and quality of life for the patient. Due to the inability of resident cells to repair damaged osteochondral tissue, researchers have focused on utilizing endogenously or exogenously sourced cells (chondrocytes or tissue-derived mesenchymal stem cells), with or without scaffolds, to encourage the secretion of extracellular matrix (ECM) that replicates this highly anisotropic osteochondral tissue, in which the phenotype of the cells and the composition and orientation of the ECM varies along its depth. Important advances have been achieved towards the development of scaffolds with macroscopically relevant structures, however, articular cartilage and bone tissue contain complex, hierarchical structures that provide cells with biophysical and biochemical cues spanning multiple length scales, presenting researchers with some substantial challenges. This review summarizes the latest advances in mechanical, biochemical and topographical engineering of biomaterials to drive requisite biological responses, such as cell differentiation and matrix deposition, in an effort to achieve functional repair of osteochondral defects.
Keyword Biomaterial
Surface engineering
Tissue engineering
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Chemical Engineering Publications
HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
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