Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling

Roy, Edwige, Neufeld, Zoltan, Cerone, Luca, Wong, Ho Yi, Hodgson, Samantha, Livet, Jean and Khosrotehrani, Kiarash (2016) Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling. EMBO Journal, 35 24: 2658-2670. doi:10.15252/embj.201693806


Author Roy, Edwige
Neufeld, Zoltan
Cerone, Luca
Wong, Ho Yi
Hodgson, Samantha
Livet, Jean
Khosrotehrani, Kiarash
Title Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling
Journal name EMBO Journal   Check publisher's open access policy
ISSN 1460-2075
0261-4189
Publication date 2016-12-15
Sub-type Article (original research)
DOI 10.15252/embj.201693806
Open Access Status Not yet assessed
Volume 35
Issue 24
Start page 2658
End page 2670
Total pages 13
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2017
Language eng
Formatted abstract
Interfollicular epidermal (IFE) homeostasis is a major physiological process allowing maintenance of the skin barrier function. Despite progress in our understanding of stem cell populations in different hair follicle compartments, cellular mechanisms of IFE maintenance, in particular, whether a hierarchy of progenitors exists within this compartment, have remained controversial. We here used multicolour lineage tracing with Brainbow transgenic labels activated in the epidermis to track individual keratinocyte clones. Two modes of clonal progression could be observed in the adult murine dorsal skin. Clones attached to hair follicles showed rapid increase in size during the growth phase of the hair cycle. On the other hand, clones distant from hair follicles were slow cycling, but could be mobilized by a proliferative stimulus. Reinforced by mathematical modelling, these data support a model where progenitor cycling characteristics are differentially regulated in areas surrounding or away from growing hair follicles. Thus, while IFE progenitors follow a non-hierarchical mode of development, spatiotemporal control by their environment can change their potentialities, with far-reaching implications for epidermal homeostasis, wound repair and cancer development.
Keyword Brainbow model
Epidermal stem cells
Hair follicle cycle
Homeostasis
Multicolour tracing model
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 03 Jan 2017, 10:35:13 EST by System User on behalf of Learning and Research Services (UQ Library)