Central nervous system nocardiosis in Queensland: a report of 20 cases and review of the literature

Rafiei, Nastaran, Peri, Anna Maria, Righi, Elda, Harris, Patrick and Paterson, David L. (2016) Central nervous system nocardiosis in Queensland: a report of 20 cases and review of the literature. Medicine, 95 46: . doi:10.1097/MD.0000000000005255


Author Rafiei, Nastaran
Peri, Anna Maria
Righi, Elda
Harris, Patrick
Paterson, David L.
Title Central nervous system nocardiosis in Queensland: a report of 20 cases and review of the literature
Journal name Medicine   Check publisher's open access policy
ISSN 0025-7974
1536-5964
Publication date 2016-11-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/MD.0000000000005255
Open Access Status DOI
Volume 95
Issue 46
Total pages 9
Place of publication Maharastra, India
Publisher Medknow Publications and Media
Collection year 2017
Language eng
Formatted abstract
Nocardia infection of the central nervous system (CNS) is an uncommon but clinically important disease, often occurring in immunocompromised individuals and carrying a high mortality rate. We present 20 cases of microbiologically proven CNS nocardiosis diagnosed in Queensland from 1997 to 2015 and review the literature from 1997 to 2016.
Over 50% of cases occurred in immunocompromised individuals, with corticosteroid use posing a particularly significant risk factor. Nine (45%) patients were immunocompetent and 3 had no comorbidities at time of diagnosis. Nocardia farcinica was the most frequently isolated species (8/20) and resistance to trimethoprim–sulfamethoxazole (TMP-SMX) was found in 2 isolates. Overall, 35% of our patients died within 1 year, with the majority of deaths occurring in the first month following diagnosis. Interestingly, of the 7 deaths occurring at 1 year, 6 were attributed to N farcinica with the seventh isolate being unspeciated, suggesting the virulence of the N farcinica strain.
Keyword Central nervous system
Nocardia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
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