Validated adherence scales used in a measurement-guided medication management approach to target and tailor a medication adherence intervention: a randomised controlled trial

Nguyen, Thi-My-Uyen, La Caze, Adam and Cottrell, Neil (2016) Validated adherence scales used in a measurement-guided medication management approach to target and tailor a medication adherence intervention: a randomised controlled trial. BMJ Open, 6 11: . doi:10.1136/bmjopen-2016-013375


Author Nguyen, Thi-My-Uyen
La Caze, Adam
Cottrell, Neil
Title Validated adherence scales used in a measurement-guided medication management approach to target and tailor a medication adherence intervention: a randomised controlled trial
Journal name BMJ Open   Check publisher's open access policy
ISSN 2044-6055
Publication date 2016-11-01
Sub-type Article (original research)
DOI 10.1136/bmjopen-2016-013375
Open Access Status DOI
Volume 6
Issue 11
Total pages 10
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Formatted abstract
Objective: To determine if a targeted and tailored intervention based on a discussion informed by validated adherence scales will improve medication adherence.

Design: Prospective randomised trial.

Setting: 2 community pharmacies in Brisbane, Australia.

Methods: Patients recently initiated on a cardiovascular or oral hypoglycaemic medication within the past 4-12 weeks were recruited from two community pharmacies. Participants identified as non-adherent using the Medication Adherence Questionnaire (MAQ) were randomised into the intervention or control group. The intervention group received a tailored intervention based on a discussion informed by responses to the MAQ, Beliefs about Medicines Questionnaire-Specific and Brief Illness Perception Questionnaire. Adherence was measured using the MAQ at 3 and 6 months following the intervention.

Results: A total of 408 patients were assessed for eligibility, from which 152 participants were enrolled into the study. 120 participants were identified as non-adherent using the MAQ and randomised to the 'intervention' or 'control' group. The mean MAQ score at baseline in the intervention and control were similar (1.58: 95% CI (1.38 to 1.78) and 1.60: 95% CI (1.43 to 1.77), respectively). There was a statistically significant improvement in adherence in the intervention group compared to control at 3 months (mean MAQ score 0.42: 95% CI (0.27 to 0.57) vs 1.58: 95% CI (1.42 to 1.75); p<0.001). The significant improvement in MAQ score in the intervention group compared to control was sustained at 6 months (0.48: 95% CI (0.31 to 0.65) vs 1.48: 95% CI (1.27 to 1.69); p<0.001).

Conclusions: An intervention that targeted non-adherent participants and tailored to participant-specific reasons for non-adherence was successful at improving medication adherence.

Trial registration number: ACTRN12613000162718; Results.
Keyword Intervention
Medication adherence
Non-adherence
Tailored
Targeted
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Pharmacy Publications
 
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