Hookworm infection

Loukas, Alex, Hotez, Peter J. , Diemert, David, Yazdanbakhsh, Maria, McCarthy, James S., Correa-Oliveira, Rodrigo, Croese, John and Bethony, Jeffrey M. (2016) Hookworm infection. Nature Reviews Disease Primers, 2 . doi:10.1038/nrdp.2016.88

Author Loukas, Alex
Hotez, Peter J. 
Diemert, David
Yazdanbakhsh, Maria
McCarthy, James S.
Correa-Oliveira, Rodrigo
Croese, John
Bethony, Jeffrey M.
Title Hookworm infection
Journal name Nature Reviews Disease Primers   Check publisher's open access policy
ISSN 2056-676X
Publication date 2016-12-08
Sub-type Article (original research)
DOI 10.1038/nrdp.2016.88
Open Access Status Not yet assessed
Volume 2
Total pages 18
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Hookworms are soil-transmitted nematode parasites that can reside for many years in the small intestine of their human hosts; Necator americanus is the predominant infecting species. Adult worms feed on the blood of a host and can cause iron deficiency anaemia, especially in high-risk populations (children and women of childbearing age). Almost 500 million people in developing tropical countries are infected, and simulation models estimate that hookworm infection is responsible for >4 million disability-adjusted life years lost annually. Humans mount an immune response to hookworms, but it is mostly unsuccessful at removing adult worms from the bowel. Accordingly, the host switches to an immune-tolerant state that enables hookworms to reside in the gut for many years. Although anthelmintic drugs are available and widely used, their efficacy varies and the drugs do not prevent reinfection. Thus, other control strategies aimed at improving water quality, sanitation and hygiene are needed. In addition, efforts are underway to develop a human hookworm vaccine through public-private partnerships. However, hookworms could also be a resource; as hookworms have the capability to regulate the host's inflammation, researchers are experimentally infecting patients to treat some inflammatory diseases as an approach to discover new anti-inflammatory molecules. This area of endeavour might well yield new biotherapeutics for autoimmune and allergic diseases.
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Sub-type: Article (original research)
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