Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

Wang, Lisa, Heckman, Michael G., Aasly, Jan O., Annesi, Grazia, Bozi, Maria, Chung, Sun Ju, Clarke, Carl, Crosiers, David, Eckstein, Gertrud, Garraux, Gaetan, Hadjigeorgiou, Georgios M., Hattori, Nobu, Jeon, Beom, Kim, Yun J., Kubo, Masato, Lesage, Suzanne, Lin, Juei Jueng, Lynch, Timothy, Lichtner, Peter, Mellick, George D., Mok, Vincent, Morrison, Karin E., Quattrone, Aldo, Satake, Wataru, Silburn, Peter A., Stefanis, Leonidas, Stockton, Joanne D., Tan, Eng King, Toda, Tatsushi, Brice, Alexis, Van Broeckhoven, Christine, Uitti, Ryan J., Wirdefeldt, Karin, Wszolek, Zbigniew, Xiromerisiou, Georgia, Maraganore, Demetrius M., Gasser, Thomas, Kruger, Rejko, Farrer, Matthew J., Ross, Owen A. and Sharma, Manu (2017) Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study. Neurobiology of Aging, 49 217.e1-217.e4. doi:10.1016/j.neurobiolaging.2016.09.022

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Author Wang, Lisa
Heckman, Michael G.
Aasly, Jan O.
Annesi, Grazia
Bozi, Maria
Chung, Sun Ju
Clarke, Carl
Crosiers, David
Eckstein, Gertrud
Garraux, Gaetan
Hadjigeorgiou, Georgios M.
Hattori, Nobu
Jeon, Beom
Kim, Yun J.
Kubo, Masato
Lesage, Suzanne
Lin, Juei Jueng
Lynch, Timothy
Lichtner, Peter
Mellick, George D.
Mok, Vincent
Morrison, Karin E.
Quattrone, Aldo
Satake, Wataru
Silburn, Peter A.
Stefanis, Leonidas
Stockton, Joanne D.
Tan, Eng King
Toda, Tatsushi
Brice, Alexis
Van Broeckhoven, Christine
Uitti, Ryan J.
Wirdefeldt, Karin
Wszolek, Zbigniew
Xiromerisiou, Georgia
Maraganore, Demetrius M.
Gasser, Thomas
Kruger, Rejko
Farrer, Matthew J.
Ross, Owen A.
Sharma, Manu
Title Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study
Journal name Neurobiology of Aging   Check publisher's open access policy
ISSN 1558-1497
0197-4580
Publication date 2017-01-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.neurobiolaging.2016.09.022
Open Access Status File (Author Post-print)
Volume 49
Start page 217.e1
End page 217.e4
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.
Keyword Genetic epidemiology
LRRK2
PARK16
Parkinson's disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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