Adverse effects of herbal or dietary supplements in G6PD deficiency: a systematic review

Lee, Shaun Wen Huey, Lai, Nai Ming, Chaiyakunapruk, Nathorn and Chong, David Weng Kwai (2017) Adverse effects of herbal or dietary supplements in G6PD deficiency: a systematic review. British Journal of Clinical Pharmacology, 83 1: 172-179. doi:10.1111/bcp.12976


Author Lee, Shaun Wen Huey
Lai, Nai Ming
Chaiyakunapruk, Nathorn
Chong, David Weng Kwai
Title Adverse effects of herbal or dietary supplements in G6PD deficiency: a systematic review
Journal name British Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 1365-2125
0306-5251
Publication date 2017-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/bcp.12976
Open Access Status Not yet assessed
Volume 83
Issue 1
Start page 172
End page 179
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Subject 3004 Pharmacology
2736 Pharmacology (medical)
Abstract Aim: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common genetic disorder, affecting nearly 400 million individuals worldwide. Whilst it is known that a number of drugs, foods and chemicals can trigger haemolysis in G6PD deficient individuals, the association between herbal and dietary supplements and haemolysis is less clear. The objective of this study was to evaluate the association between herbal or dietary supplements and adverse events in G6PD deficient individuals. Methods: We searched 14 electronic databases from their inception until November 2015 for articles describing the use of herbal or dietary supplements in G6PD deficient individuals. Additional publications were identified from manually searching textbooks, conference abstracts and the grey literature. All study designs were included as long as they contained clinical information. These gathered findings were summarized narratively. Results: Thirty-two publications met inclusion criteria. These reported on 10 herbal and dietary supplements. Overall evidence linking haemolysis to a herbal/dietary supplement was only found for henna. No evidence of harm was observed for vitamin C, vitamin E, vitamin K, Gingko biloba and α-lipoic acid. Conclusions: The review showed that there was insufficient evidence to contravene the use of most herbal or dietary products at therapeutic doses in G6PD deficient subjects.
Formatted abstract
Aim: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common genetic disorder, affecting nearly 400 million individuals worldwide. Whilst it is known that a number of drugs, foods and chemicals can trigger haemolysis in G6PD deficient individuals, the association between herbal and dietary supplements and haemolysis is less clear. The objective of this study was to evaluate the association between herbal or dietary supplements and adverse events in G6PD deficient individuals.

Methods: We searched 14 electronic databases from their inception until November 2015 for articles describing the use of herbal or dietary supplements in G6PD deficient individuals. Additional publications were identified from manually searching textbooks, conference abstracts and the grey literature. All study designs were included as long as they contained clinical information. These gathered findings were summarized narratively.

Results: Thirty-two publications met inclusion criteria. These reported on 10 herbal and dietary supplements. Overall evidence linking haemolysis to a herbal/dietary supplement was only found for henna. No evidence of harm was observed for vitamin C, vitamin E, vitamin K, Gingko biloba and α-lipoic acid.

Conclusions: The review showed that there was insufficient evidence to contravene the use of most herbal or dietary products at therapeutic doses in G6PD deficient subjects.
Keyword Glucose-6-phosphate dehydrogenase
Herbal medicine
Safety
Systematic review
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
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