Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Barban, Nicola, Jansen, Rick, de Vlaming, Ronald, Vaez, Ahmad, Mandemakers, Jornt J., Tropf, Felix C., Shen, Xia, Wilson, James F., Chasman, Daniel I., Nolte, Illa M., Tragante, Vinicius, van der Laan, Sander W., Perry, John R. B., Kong, Augustine, Ahluwalia, Tarunveer S., Albrecht, Eva, Yerges-Armstrong, Laura, Atzmon, Gil, Auro, Kirsi, Ayers, Kristin, Bakshi, Andrew, Ben-Avraham, Danny, Berger, Klaus, Bergman, Aviv, Bertram, Lars, Bielak, Lawrence F., Bjornsdottir, Gyda, Bonder, Marc Jan, Broer, Linda, Bui, Minh, Barbieri, Caterina, Cavadino, Alana, Chavarro, Jorge E., Turman, Constance, Concas, Maria Pina, Cordell, Heather J., Davies, Gail, Eibich, Peter, Eriksson, Nicholas, Esko, Tonu, Eriksson, Joel, Falahi, Fahimeh, Felix, Janine F., Fontana, Mark Alan, Franke, Lude, Gandin, Ilaria, Gaskins, Audrey J., Gieger, Christian, Gunderson, Erica P., Guo, Xiuqing, Hayward, Caroline, He, Chunyan, Hofer, Edith, Huang, Hongyan, Joshi, Peter K., Kanoni, Stavroula, Karlsson, Robert, Kiechl, Stefan, Kifley, Annette, Kluttig, Alexander, Kraft, Peter, Lagou, Vasiliki, Lecoeur, Cecile, Lahti, Jari, Li-Gao, Ruifang, Lind, Penelope A., Liu, Tian, Makalic, Enes, Mamasoula, Crysovalanto, Matteson, Lindsay, Mbarek, Hamdi, McArdle, Patrick F., McMahon, George, Meddens, S. Fleur W., Mihailov, Evelin, Miller, Mike, Missmer, Stacey A., Monnereau, Claire, van der Most, Peter J., Myhre, Ronny, Nalls, Mike A., Nutile, Teresa, Kalafati, Ioanna Panagiota, Porcu, Eleonora, Prokopenko, Inga, Rajan, Kumar B., Rich-Edwards, Janet, Rietveld, Cornelius A., Robino, Antonietta, Rose, Lynda M., Rueedi, Rico, Ryan, Kathleen-A, Saba, Yasaman, Schmidt, Daniel, Smith, Jennifer A., Stolk, Lisette, Streeten, Elizabeth, Toenjes, Anke, Thorleifsson, Gudmar, Ulivi, Sheila, Wedenoja, Juho, Wellmann, Juergen, Willeit, Peter, Yao, Jie, Yengo, Loic, Zhao, Jing Hua, Zhao, Wei, Zhernakova, Dania V., Amin, Najaf, Andrews, Howard, Balkau, Beverley, Barzilai, Nir, Bergmann, Sven, Biino, Ginevra, Bisgaard, Hans, Bonnelykke, Klaus, Boomsma, Dorret I., Buring, Julie E., Campbell, Harry, Cappellani, Stefania, Ciullo, Marina, Cox, Simon R., Cucca, Francesco, Toniolo, Daniela, Davey-Smith, George, Deary, Ian J., Dedoussis, George, Deloukas, Panos, van Duijn, Cornelia M., de Geus, Eco J. C., Eriksson, Johan G., Evans, Denis A., Faul, Jessica D., Sala, Cinzia Felicita, Froguel, Philippe, Gasparini, Paolo, Girotto, Giorgia, Grabe, Hans-Joergen, Greiser, Karin Halina, Groenen, Patrick J. F., de Haan, Hugoline G., Haerting, Johannes, Harris, Tamara B., Heath, Andrew C., Heikkila, Kauko, Hofman, Albert, Homuth, Georg, Holliday, Elizabeth G., Hopper, John, Hypponen, Elina, Jacobsson, Bo, Jaddoe', Vincent W. V., Johannesson, Magnus, Kahonen, Mika, Kajantie, Eero, Kardia, Sharon L. R., Keavney, Bernard, Kolcic, Ivana, Koponen, Paivikki, Kovacs, Peter, Kronenberg, Florian, Kutalik, Zoltan, La Bianca, Martina, Lachance, Genevieve, Iacono, William G., Lai, Sandra, Lehtimaki, Terho, Liewald, David C., Lindgren, Cecilia M., Liu, Yongmei, Luben, Robert, Lucht, Michael, Luoto, Riitta, Magnus, Per, Magnusson, Patrik K. E., Martin, Nicholas G., McGue, Matt, McQuillan, Ruth, Medland, Sarah E., Meisinger, Christa, Mellstrom, Dan, Metspalu, Andres, Traglia, Michela, Milani, Lili, Mitchell, Paul, Montgomery, Grant W., Mook-Kanamori, Dennis, de Mutsert, Renee, Nohr, Ellen A., Ohlsson, Claes, Olsen, Porn, Ong, Ken K., Paternoster, Lavinia, Pattie, Alison, Penninx, Brenda W. J. H., Perola, Markus, Peyser, Patricia A., Pirastu, Mario, Polasek, Ozren, Power, Chris, Kaprio, Jaakko, Raffel, Leslie J., Raikkonen, Katri, Raitakari, Olli, Ridker, Paul M., Ring, Susan M., Roll, Kathryn, Rudan, Igor, Ruggiero, Daniela, Rujescu, Dan, Salomaa, Veikko, Schlessinger, David, Schmidt, Helena, Schmidt, Reinhold, Schupf, Nicole, Smit, Johannes, Sorice, Rossella, Spector, Tim D., Starr, John M., Stockl, Doris, Strauch, Konstantin, Stumvoll, Michael, Swertz, Morris A., Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Tung, Joyce Y., Uitterlinden, Andre G., Vaccargiu, Simona, Viikari, Jorma, Vitart, Veronique, Voelzke, Henry, Vollenweider, Peter, Vuckovic, Dragana, Waage, Johannes, Wagner, Gert G., Wang, Jie Jin, Wareham, Nicholas J., Weir, David R., Willemsen, Gonneke, Willeit, Johann, Wright, Alan F., Zondervan, Krina T., Stefansson, Kari, Krueger, Robert F., Lee, James J., Benjamin, Daniel J., Cesarini, David, Koellinger, Philipp D., den Hoed, Marcel, Snieder, Harold and Mills, Melinda C. (2016) Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics, 48 12: 1462-1472. doi:10.1038/ng.3698


Author Barban, Nicola
Jansen, Rick
de Vlaming, Ronald
Vaez, Ahmad
Mandemakers, Jornt J.
Tropf, Felix C.
Shen, Xia
Wilson, James F.
Chasman, Daniel I.
Nolte, Illa M.
Tragante, Vinicius
van der Laan, Sander W.
Perry, John R. B.
Kong, Augustine
Ahluwalia, Tarunveer S.
Albrecht, Eva
Yerges-Armstrong, Laura
Atzmon, Gil
Auro, Kirsi
Ayers, Kristin
Bakshi, Andrew
Ben-Avraham, Danny
Berger, Klaus
Bergman, Aviv
Bertram, Lars
Bielak, Lawrence F.
Bjornsdottir, Gyda
Bonder, Marc Jan
Broer, Linda
Bui, Minh
Barbieri, Caterina
Cavadino, Alana
Chavarro, Jorge E.
Turman, Constance
Concas, Maria Pina
Cordell, Heather J.
Davies, Gail
Eibich, Peter
Eriksson, Nicholas
Esko, Tonu
Eriksson, Joel
Falahi, Fahimeh
Felix, Janine F.
Fontana, Mark Alan
Franke, Lude
Gandin, Ilaria
Gaskins, Audrey J.
Gieger, Christian
Gunderson, Erica P.
Guo, Xiuqing
Hayward, Caroline
He, Chunyan
Hofer, Edith
Huang, Hongyan
Joshi, Peter K.
Kanoni, Stavroula
Karlsson, Robert
Kiechl, Stefan
Kifley, Annette
Kluttig, Alexander
Kraft, Peter
Lagou, Vasiliki
Lecoeur, Cecile
Lahti, Jari
Li-Gao, Ruifang
Lind, Penelope A.
Liu, Tian
Makalic, Enes
Mamasoula, Crysovalanto
Matteson, Lindsay
Mbarek, Hamdi
McArdle, Patrick F.
McMahon, George
Meddens, S. Fleur W.
Mihailov, Evelin
Miller, Mike
Missmer, Stacey A.
Monnereau, Claire
van der Most, Peter J.
Myhre, Ronny
Nalls, Mike A.
Nutile, Teresa
Kalafati, Ioanna Panagiota
Porcu, Eleonora
Prokopenko, Inga
Rajan, Kumar B.
Rich-Edwards, Janet
Rietveld, Cornelius A.
Robino, Antonietta
Rose, Lynda M.
Rueedi, Rico
Ryan, Kathleen-A
Saba, Yasaman
Schmidt, Daniel
Smith, Jennifer A.
Stolk, Lisette
Streeten, Elizabeth
Toenjes, Anke
Thorleifsson, Gudmar
Ulivi, Sheila
Wedenoja, Juho
Wellmann, Juergen
Willeit, Peter
Yao, Jie
Yengo, Loic
Zhao, Jing Hua
Zhao, Wei
Zhernakova, Dania V.
Amin, Najaf
Andrews, Howard
Balkau, Beverley
Barzilai, Nir
Bergmann, Sven
Biino, Ginevra
Bisgaard, Hans
Bonnelykke, Klaus
Boomsma, Dorret I.
Buring, Julie E.
Campbell, Harry
Cappellani, Stefania
Ciullo, Marina
Cox, Simon R.
Cucca, Francesco
Toniolo, Daniela
Davey-Smith, George
Deary, Ian J.
Dedoussis, George
Deloukas, Panos
van Duijn, Cornelia M.
de Geus, Eco J. C.
Eriksson, Johan G.
Evans, Denis A.
Faul, Jessica D.
Sala, Cinzia Felicita
Froguel, Philippe
Gasparini, Paolo
Girotto, Giorgia
Grabe, Hans-Joergen
Greiser, Karin Halina
Groenen, Patrick J. F.
de Haan, Hugoline G.
Haerting, Johannes
Harris, Tamara B.
Heath, Andrew C.
Heikkila, Kauko
Hofman, Albert
Homuth, Georg
Holliday, Elizabeth G.
Hopper, John
Hypponen, Elina
Jacobsson, Bo
Jaddoe', Vincent W. V.
Johannesson, Magnus
Kahonen, Mika
Kajantie, Eero
Kardia, Sharon L. R.
Keavney, Bernard
Kolcic, Ivana
Koponen, Paivikki
Kovacs, Peter
Kronenberg, Florian
Kutalik, Zoltan
La Bianca, Martina
Lachance, Genevieve
Iacono, William G.
Lai, Sandra
Lehtimaki, Terho
Liewald, David C.
Lindgren, Cecilia M.
Liu, Yongmei
Luben, Robert
Lucht, Michael
Luoto, Riitta
Magnus, Per
Magnusson, Patrik K. E.
Martin, Nicholas G.
McGue, Matt
McQuillan, Ruth
Medland, Sarah E.
Meisinger, Christa
Mellstrom, Dan
Metspalu, Andres
Traglia, Michela
Milani, Lili
Mitchell, Paul
Montgomery, Grant W.
Mook-Kanamori, Dennis
de Mutsert, Renee
Nohr, Ellen A.
Ohlsson, Claes
Olsen, Porn
Ong, Ken K.
Paternoster, Lavinia
Pattie, Alison
Penninx, Brenda W. J. H.
Perola, Markus
Peyser, Patricia A.
Pirastu, Mario
Polasek, Ozren
Power, Chris
Kaprio, Jaakko
Raffel, Leslie J.
Raikkonen, Katri
Raitakari, Olli
Ridker, Paul M.
Ring, Susan M.
Roll, Kathryn
Rudan, Igor
Ruggiero, Daniela
Rujescu, Dan
Salomaa, Veikko
Schlessinger, David
Schmidt, Helena
Schmidt, Reinhold
Schupf, Nicole
Smit, Johannes
Sorice, Rossella
Spector, Tim D.
Starr, John M.
Stockl, Doris
Strauch, Konstantin
Stumvoll, Michael
Swertz, Morris A.
Thorsteinsdottir, Unnur
Thurik, A. Roy
Timpson, Nicholas J.
Tung, Joyce Y.
Uitterlinden, Andre G.
Vaccargiu, Simona
Viikari, Jorma
Vitart, Veronique
Voelzke, Henry
Vollenweider, Peter
Vuckovic, Dragana
Waage, Johannes
Wagner, Gert G.
Wang, Jie Jin
Wareham, Nicholas J.
Weir, David R.
Willemsen, Gonneke
Willeit, Johann
Wright, Alan F.
Zondervan, Krina T.
Stefansson, Kari
Krueger, Robert F.
Lee, James J.
Benjamin, Daniel J.
Cesarini, David
Koellinger, Philipp D.
den Hoed, Marcel
Snieder, Harold
Mills, Melinda C.
Title Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1546-1718
1061-4036
Publication date 2016-10-31
Sub-type Article (original research)
DOI 10.1038/ng.3698
Open Access Status Not yet assessed
Volume 48
Issue 12
Start page 1462
End page 1472
Total pages 11
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Subject 1311 Genetics
Abstract The genetic architecture of human reproductive behavior - age at first birth (AFB) and number of children ever born (NEB) - has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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