Stimulation of dorsolateral prefrontal cortex Enhances adaptive cognitive control: a high-definition transcranial direct current stimulation study

Gbadeyan, Oyetunde, McMahon, Katie, Steinhauser, Marco and Meinzer, Marcus (2016) Stimulation of dorsolateral prefrontal cortex Enhances adaptive cognitive control: a high-definition transcranial direct current stimulation study. Journal of Neuroscience, 36 50: 12530-12536. doi:10.1523/JNEUROSCI.2450-16.2016

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ415933_OA.pdf Full text (open access) application/pdf Bytes 0

Author Gbadeyan, Oyetunde
McMahon, Katie
Steinhauser, Marco
Meinzer, Marcus
Title Stimulation of dorsolateral prefrontal cortex Enhances adaptive cognitive control: a high-definition transcranial direct current stimulation study
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
1529-2401
Publication date 2016-12-14
Year available 2016
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.2450-16.2016
Open Access Status File (Publisher version)
Volume 36
Issue 50
Start page 12530
End page 12536
Total pages 7
Place of publication Washington, DC, United States
Publisher Society for Neuroscience
Language eng
Subject 2800 Neuroscience
Abstract Conflict adaptation is a hallmark effect of adaptive cognitive control and refers to the adjustment of control to the level of previously experienced conflict. Conflict monitoring theory assumes that the dorsolateral prefrontal cortex (DLPFC) is causally involved in this adjustment. However,to date, evidence in humans is predominantly correlational, and heterogeneous with respecttothe lateralization of control in the DLPFC. We used high-definition transcranial direct current stimulation (HD-tDCS), which allows for more focal current delivery than conventional tDCS, to clarify the causal involvement of the DLPFC in conflict adaptation. Specifically, we investigated the regional specificity and lateralization of potential beneficial stimulation effects on conflict adaptation during a visual flanker task. One hundred twenty healthy participants were assigned to four HD-tDCS conditions: left or right DLPFC or left or right primary motor cortex (M1). Each group underwent both active and sham HD-tDCS in crossover, double-blind designs. We obtained a sizeable conflict adaptation effect (measured as the modulation of the flanker effect as a function of previous response conflict) in all groups and conditions. However,this effect was larger under active HD-tDCSthan under sham stimulation in both DLPFC groups. In contrast, active stimulation had no effect on conflict adaptation in the M1 groups. In sum, the present results indicate that the DLPFC plays a causal role in adaptive cognitive control, but that the involvement of DLPFC in control is not restricted to the left or right hemisphere. Moreover, our study confirms the potential of HD-tDCS to modulate cognition in a regionally specific manner.
Keyword Brain stimulation
Cognitive control
Conflict adaptation
Conflict monitoring theory
Dorsolateral prefrontal cortex
High-definition transcranial direct current stimulation
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID FT120100608.
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
HERDC Pre-Audit
Centre for Advanced Imaging Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 23 Dec 2016, 20:13:09 EST by Marcus Meinzer on behalf of School of Health & Rehabilitation Sciences