Osteoconduction in keratin-hydroxyapatite composite bone-graft substitutes

Dias, George Jayantha, Mahoney, Patricia, Hung, Noelyn Anne, Sharma, Lavanya Ajay, Kalita, Priyakshi, Smith, Robert Allen, Kelly, Robert James and Ali, Azam (2016) Osteoconduction in keratin-hydroxyapatite composite bone-graft substitutes. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 105 7: 2034-2044. doi:10.1002/jbm.b.33735

Author Dias, George Jayantha
Mahoney, Patricia
Hung, Noelyn Anne
Sharma, Lavanya Ajay
Kalita, Priyakshi
Smith, Robert Allen
Kelly, Robert James
Ali, Azam
Title Osteoconduction in keratin-hydroxyapatite composite bone-graft substitutes
Journal name Journal of Biomedical Materials Research. Part B: Applied Biomaterials   Check publisher's open access policy
ISSN 1552-4981
Publication date 2016-07-08
Sub-type Article (original research)
DOI 10.1002/jbm.b.33735
Volume 105
Issue 7
Start page 2034
End page 2044
Total pages 11
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Reconstituted keratin-hydroxyapatite (K-HA) composites have shown potential as nonload-bearing bone graft substitute material. This in vivo study investigated the bone regeneration response of keratin plus 40% HA composite materials in comparison to collagen counterparts and an unfilled defect site. The implantation site was a noncritical size defect created in the long bones (tibia) of sheep, with observations made at 1, 2, 4, 6, 8, and 12 weeks postimplantation. Porous K-HA materials displayed an excellent biocompatibility similar to collagen counterparts; however, the rate of bone regeneration at K-HA implantation sites was markedly slower than that of the collagen or unfilled defect sites. While collagen materials were undetectable by 4 weeks implantation, K-HA composite remnants were present at 12 weeks. However, there is evidence that K-HA implants participated in the natural remodelling process of bone, with bone regeneration occurring via a creeping substitution mechanism. Observations imply that the rate of bone ingrowth into the K-HA defect site was matched with the rate of K-HA resorption. These results suggest that K-HA materials may offer significant benefits as nonload-bearing bone graft substitutes where it is desirable that the degradation of the scaffolding material be well matched with the rate of bone regeneration.
Keyword Keratin
Bone graft substitute
Creeping substitution
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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Created: Tue, 20 Dec 2016, 22:01:28 EST by Priyakshi Kalita-de Croft on behalf of UQ Centre for Clinical Research