Changes in non-diabetic comorbid disease status following laparoscopic vertical sleeve gastrectomy (LVSG) versus laparoscopic Roux-en-Y gastric bypass (LRYGB) procedures: a systematic review of randomized controlled trials

Osland, Emma, Yunus, Rossita Mohamad, Khan, Shahjahan, Memon, Breda and Memon, Muhammed Ashraf (2016) Changes in non-diabetic comorbid disease status following laparoscopic vertical sleeve gastrectomy (LVSG) versus laparoscopic Roux-en-Y gastric bypass (LRYGB) procedures: a systematic review of randomized controlled trials. Obesity Surgery, 27 5: 1-14. doi:10.1007/s11695-016-2469-5


Author Osland, Emma
Yunus, Rossita Mohamad
Khan, Shahjahan
Memon, Breda
Memon, Muhammed Ashraf
Title Changes in non-diabetic comorbid disease status following laparoscopic vertical sleeve gastrectomy (LVSG) versus laparoscopic Roux-en-Y gastric bypass (LRYGB) procedures: a systematic review of randomized controlled trials
Journal name Obesity Surgery   Check publisher's open access policy
ISSN 1708-0428
0960-8923
Publication date 2016-11-28
Year available 2017
Sub-type Article (original research)
DOI 10.1007/s11695-016-2469-5
Open Access Status Not yet assessed
Volume 27
Issue 5
Start page 1
End page 14
Total pages 14
Place of publication New York, NY, United States
Publisher Springer New York LLC
Language eng
Subject 2746 Surgery
2712 Endocrinology, Diabetes and Metabolism
2916 Nutrition and Dietetics
Abstract Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic vertical sleeve gastrectomy (LVSG) have been proposed as cost-effective strategies to manage obesity-related chronic disease. The aim of this systematic review was to study the peer review literature regarding postoperative nondiabetic comorbid disease resolution or improvement reported from randomized controlled trials (RCTs) comparing LVSG and LRYGB procedures.
Formatted abstract
Purpose: Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic vertical sleeve gastrectomy (LVSG) have been proposed as cost-effective strategies to manage obesity-related chronic disease. The aim of this systematic review was to study the peer review literature regarding postoperative nondiabetic comorbid disease resolution or improvement reported from randomized controlled trials (RCTs) comparing LVSG and LRYGB procedures.

Material and Methods: RCTs comparing postoperative comorbid disease resolution such as hypertension, dyslipidemia, obstructive sleep apnea, joint and musculoskeletal conditions, gastroesophageal reflux disease, and menstrual irregularities following LVSG and LRYGB were included for analysis. The studies were selected from PubMed, Medline, EMBASE, Science Citation Index, Current Contents, and the Cochrane database and reported on at least one comorbidity resolution or improvement. The present work was undertaken according to the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA). The Jadad method for assessment of methodological quality was applied to the included studies.

Results: Six RCTs performed between 2005 and 2015 involving a total of 695 patients (LVSG n = 347, LRYGB n = 348) reported on the resolution or improvement of comorbid disease following LVSG and LRYGB procedures. Both bariatric procedures provide effective and almost comparable results in improving or resolving these comorbidities.

Conclusions: This systematic review of RCTs suggests that both LVSG and LRYGB are effective in resolving or improving preoperative nondiabetic comorbid diseases in obese patients. While results are not conclusive at this time, LRYGB may provide superior results compared to LVSG in mediating the remission and/or improvement in some conditions such as dyslipidemia and arthritis.
Keyword Dyslipidemia
Gastroesophageal reflux disease
Hypertension
Laparoscopic
Menstrual irregularities
Musculoskeletal disorders
Obesity
Obstructive sleep apnea
Randomized controlled trials
Roux-en-Y gastric bypass
Sleeve gastrectomy
Systematic review
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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