A gadolinium(III) complex based dual-modal probe for MRI and fluorescence sensing of fluoride ions in aqueous medium and: in vivo

Wang, Yue, Song, Renfeng, Guo, Ke, Meng, Qingtao, Zhang, Run, Kong, Xiangfeng and Zhang, Zhiqiang (2016) A gadolinium(III) complex based dual-modal probe for MRI and fluorescence sensing of fluoride ions in aqueous medium and: in vivo. Dalton Transactions, 45 44: 17616-17623. doi:10.1039/c6dt02229d


Author Wang, Yue
Song, Renfeng
Guo, Ke
Meng, Qingtao
Zhang, Run
Kong, Xiangfeng
Zhang, Zhiqiang
Title A gadolinium(III) complex based dual-modal probe for MRI and fluorescence sensing of fluoride ions in aqueous medium and: in vivo
Formatted title
A gadolinium(III) complex based dual-modal probe for MRI and fluorescence sensing of fluoride ions in aqueous medium and: in vivo
Journal name Dalton Transactions   Check publisher's open access policy
ISSN 1477-9234
1477-9226
Publication date 2016-11-28
Sub-type Article (original research)
DOI 10.1039/c6dt02229d
Open Access Status Not yet assessed
Volume 45
Issue 44
Start page 17616
End page 17623
Total pages 8
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Language eng
Abstract A novel Gd(iii) complex, Gd(TTA)3-DPPZ, was designed and assembled as a dual-modal probe for the simultaneous fluorescence and magnetic resonance imaging (MRI) detection of fluoride ions in aqueous media and in vivo. In this system, the Gd(iii) center is not only serving as a MRI signal output unit, but also as a binding site for fluoride ions. When appropriate equivalents of fluoride ions were added into the solution of Gd(TTA)3-DPPZ, the replacement of the coordination water led to a decrease of the longitudinal relaxivity (r1) as well as distinct spectroscopic changes, by which MRI/fluorescence dual-modal fluoride ion sensing was achieved. In the presence of fluoride ions, a 2-fold fluorescence emission enhancement of Gd(TTA)3-DPPZ, and a notable decrease of the UV-vis absorption spectrum were observed. The fluorescence detection limit for fluoride ions was established at 70 nM. Gd(TTA)3-DPPZ also exhibits about 75% decrease of the longitudinal relaxivity (r1) upon addition of fluoride ions in aqueous medium. The appropriate blood circulation time of Gd(TTA)3-DPPZ allows its potential application in MRI in vivo. The results demonstrated that Gd(TTA)3-DPPZ could serve as a potential MRI/fluorescence bimodal imaging agent for the specific and high-sensitive sensing of fluoride ions in vivo.
Formatted abstract
A novel Gd(III) complex, Gd(TTA)3-DPPZ, was designed and assembled as a dual-modal probe for the simultaneous fluorescence and magnetic resonance imaging (MRI) detection of fluoride ions in aqueous media and in vivo. In this system, the Gd(III) center is not only serving as a MRI signal output unit, but also as a binding site for fluoride ions. When appropriate equivalents of fluoride ions were added into the solution of Gd(TTA)3-DPPZ, the replacement of the coordination water led to a decrease of the longitudinal relaxivity (r1) as well as distinct spectroscopic changes, by which MRI/fluorescence dual-modal fluoride ion sensing was achieved. In the presence of fluoride ions, a 2-fold fluorescence emission enhancement of Gd(TTA)3-DPPZ, and a notable decrease of the UV-vis absorption spectrum were observed. The fluorescence detection limit for fluoride ions was established at 70 nM. Gd(TTA)3-DPPZ also exhibits about 75% decrease of the longitudinal relaxivity (r1) upon addition of fluoride ions in aqueous medium. The appropriate blood circulation time of Gd(TTA)3-DPPZ allows its potential application in MRI in vivo. The results demonstrated that Gd(TTA)3-DPPZ could serve as a potential MRI/fluorescence bimodal imaging agent for the specific and high-sensitive sensing of fluoride ions in vivo.
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Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
 
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