Case Study 1: Development of the Analgesic Drugs Prialt (R) and Xen2174 from Cone Snail Venoms

Lewis, Richard J. (2015). Case Study 1: Development of the Analgesic Drugs Prialt (R) and Xen2174 from Cone Snail Venoms. In Venoms to drugs: venom as a source for the development of human therapeutics (pp. 245-254) Cambridge, United States: RSC. doi:10.1039/9781849737876-00245


Author Lewis, Richard J.
Title of chapter Case Study 1: Development of the Analgesic Drugs Prialt (R) and Xen2174 from Cone Snail Venoms
Title of book Venoms to drugs: venom as a source for the development of human therapeutics
Place of Publication Cambridge, United States
Publisher RSC
Publication Year 2015
Sub-type Research book chapter (original research)
DOI 10.1039/9781849737876-00245
Open Access Status Not yet assessed
ISBN 9781849736633
ISSN 2041-3203
Chapter number 9
Start page 245
End page 254
Total pages 10
Total chapters 12
Language eng
Formatted Abstract/Summary
Cone snail venoms are a rich source of small, structurally constrained peptides (conotoxins) that are widely used as research tools and as a source of promising leads to potential therapies. At least 15 pharmacological classes of conotoxins have been characterized, including clinically evaluated ω-conotoxins that inhibit the voltage-gated calcium channel Cav2.2 and χ-conopeptides that inhibit the noradrenaline transporter. The ω-conotoxins isolated from piscivorous snails and χ-conopeptides from molluscivorous snails produce analgesia when administered intrathecally in rodent models of neuropathic pain, by either directly or indirectly inhibiting Cav2.2. Open label studies showed that intrathecal ω-MVIIA (Prialt®), ω-CVID (Leconitide) and χ-Xen2174 reduced pain scores in cancer patients suffering severe chronic pain. This review compares and contrasts these two classes of venom peptide and the pain pathways they inhibit.
Keyword Calcium-Channel Blocker
Omega-Conotoxin Gvia
N-Type
Neuropathic Pain
Chi-Conopeptide
Nerve-Terminals
Rats
Antinociception
Release
Hyperalgesia
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Book Chapter
Collection: Institute for Molecular Bioscience - Publications
 
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