Study of alanine aminopeptidase excretion as a test of gentamicin nephrotoxicity

Davey, PG, Geddes, AM and Cowley, DM (1983) Study of alanine aminopeptidase excretion as a test of gentamicin nephrotoxicity. Journal of Antimicrobial Chemotherapy, 11 5: 455-465. doi:10.1093/jac/11.5.455


Author Davey, PG
Geddes, AM
Cowley, DM
Title Study of alanine aminopeptidase excretion as a test of gentamicin nephrotoxicity
Journal name Journal of Antimicrobial Chemotherapy   Check publisher's open access policy
ISSN 0305-7453
Publication date 1983-01-01
Sub-type Article (original research)
DOI 10.1093/jac/11.5.455
Volume 11
Issue 5
Start page 455
End page 465
Total pages 11
Language eng
Subject 1804 Statistics, Probability and Uncertainty
2604 Applied Mathematics
2737 Physiology (medical)
2725 Infectious Diseases
2736 Pharmacology (medical)
3004 Pharmacology
2404 Microbiology
Abstract We studied the urinary excretion of the proximal tubular enzyme alanine aminopeptidase (AAP) by 38 patients who received gentamicin and by 45 similar control patients. AAP excretion by the control patients was highly variable. The pattern of AAP excretion distinguished patients with pre-renal and renal causes for increases in serum creatinine (SCr) but this can be done more simply with the urine to serum creatinine ratio. Peak AAP excretion did not reflect renal damage in oliguric patients and did not identify gentamicin patients with a renal cause for increases in SCr. The level of AAP excretion in the first three days of gentamicin treatment did identify the three patients with renal causes for an increase in SCr and was highest in a patient with symptomatic hypomagnesaemia due to impairment of proximal tubular function. We concluded that study of AAP excretion in normal volunteers receiving three-day courses of aminoglycosides is a valid screening test for nephrotoxicity but that AAP excretion is too non-specific to use in clinical practice.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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