The ins and outs of calcium signalling in lactation and involution: implications for breast cancer treatment

Davis, Felicity M. (2017) The ins and outs of calcium signalling in lactation and involution: implications for breast cancer treatment. Pharmacological Research, 116 100-104. doi:10.1016/j.phrs.2016.12.007

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Author Davis, Felicity M.
Title The ins and outs of calcium signalling in lactation and involution: implications for breast cancer treatment
Journal name Pharmacological Research   Check publisher's open access policy
ISSN 1043-6618
1096-1186
Publication date 2017-02-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.phrs.2016.12.007
Open Access Status File (Author Post-print)
Volume 116
Start page 100
End page 104
Total pages 5
Place of publication London, United Kingdom
Publisher Academic Press
Collection year 2017
Language eng
Formatted abstract
The mammary epithelium is highly responsive to hormonal and non-hormonal signalling cues for physiological growth, function and tissue remodelling. Whilst steroid hormones freely diffuse across the cell membrane to bind to intracellular hormone receptors, cell-impermeable ligands, including many peptide hormones, growth factors and cytokines, bind to receptors on the plasma membrane and relay their message via the specific activation of intracellular signal transduction pathways. A signalling pathway that is indispensable for decoding many extracellular signals into cellular responses is calcium (Ca2+). Changes in the expression of specific Ca2+ channels, pumps and binding proteins may therefore greatly alter the nature of the cellular response to various growth, morphogenetic and cell death stimuli. This review summarises changes in the expression, localisation and function of key Ca2+ channels and pumps in mammary epithelial cells during lactation and discusses how this altered Ca2+ handling may later expose these cells to targeted cell death during post-lactational involution. A greater understanding of the processes regulating the growth, death and regeneration of the mammary epithelium under physiological conditions may provide important insights into the proliferation and survival mechanisms underpinning malignant growth. The therapeutic manipulation of specific calcium signalling pathways in breast cancer cells to control aberrant cell proliferation and/or turnover represents an aim for the future.
Keyword Lactation
Involution
Mammary gland
Ca2+ channels and pumps
Store-operated calcium entry
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
HERDC Pre-Audit
School of Pharmacy Publications
 
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Created: Mon, 12 Dec 2016, 01:28:37 EST by Miss Felicity Davis on behalf of School of Pharmacy