Urinary porphyrin profile as an early warning biomarker in C57BL/6J mice chronically exposed to monomethylarsonous acid (MMA(III))

Manonmanii, K., Wu, Huijie, Wang, J. P., Moore, Michael R. and Ng, Jack C. (2004). Urinary porphyrin profile as an early warning biomarker in C57BL/6J mice chronically exposed to monomethylarsonous acid (MMA(III)). In: Toxicology and Applied Pharmacology. Proceedings of: 10th International Congress of Toxicology (ICTX). 10th International Congress of Toxicology (ICTX), Tampere, Finland, (197-197). 11-15 July 2004. doi:10.1016/j.taap.2004.04.002


Author Manonmanii, K.
Wu, Huijie
Wang, J. P.
Moore, Michael R.
Ng, Jack C.
Title of paper Urinary porphyrin profile as an early warning biomarker in C57BL/6J mice chronically exposed to monomethylarsonous acid (MMA(III))
Formatted title
Urinary porphyrin profile as an early warning biomarker in C57BL/6J mice chronically exposed to monomethylarsonous acid (MMAIII)
Conference name 10th International Congress of Toxicology (ICTX)
Conference location Tampere, Finland
Conference dates 11-15 July 2004
Proceedings title Toxicology and Applied Pharmacology. Proceedings of: 10th International Congress of Toxicology (ICTX)   Check publisher's open access policy
Journal name Toxicology and Applied Pharmacology   Check publisher's open access policy
Place of Publication New York, U. S. A.
Publisher Academic Press
Publication Year 2004
Sub-type Published abstract
DOI 10.1016/j.taap.2004.04.002
ISSN 0041-008X
1096-0333
Volume 197
Issue 3
Start page 197
End page 197
Total pages 1
Language eng
Formatted Abstract/Summary
MMAIII is found to be more acutely toxic and more genotoxic than arsenite and arsenate. Arsenic is known to affect the activity of enzymes responsible for haem biosynthesis. Urinary porphyrin profile may be a good early warning biomarker for carcinogenesis in mice chronically exposed to arsenic. As a part of 2-year arsenic carcinogenicity study, young female C57BL/6J mice are given drinking water containing 0, 100, 250 and 500 μg Arsenic as MMAIII ad libitum. 24 h Urine samples are collected every 8 weeks for arsenic speciation study and other biomarkers. After 32 weeks of exposure, coproporphyrin III was the dominant porphyrin in the urine of these mice, whereas concentrations of coproporphyrin I and uroporphyrin were similar but, several times lower initially and more than an order of magnitude lower than coproporphyrin III by 32 weeks of age and exposure. Total urinary porphyrin for the control and treatment groups increased with age. The increase among the treatment groups was in a dose response manner in 24 weeks. The increases in 24 and 32 weeks were the highest compared to the control group. The coproporphyrin profiles were similar to those of total porphyrin against exposure time. This reflects the dominance of coproporphyrin III in the urine. Uroporphyrin shows dose response related increase after 2, 4, and 8 weeks exposure. This experiment will continue for another 16 months. The results so far, indicate that the urinary porphyrin concentration may be used as an early warning indicator for arsenic exposure. It will be interesting to study the overall porphyrin profile over 2 years (as an indicator) and to evaluate the effect of MMAIII on haem biosnythesis.
Subjects EX
321299 Public Health and Health Services not elsewhere classified
730210 Environmental health
1115 Pharmacology and Pharmaceutical Sciences
Keyword Pharmacology & pharmacy
Toxicology
Q-Index Code EX
Additional Notes Paper number 280

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Google Scholar Search Google Scholar
Created: Tue, 14 Aug 2007, 00:25:04 EST