Immune-challenged fish up-regulate their metabolic scope to support locomotion

Bonneaud, Camille, Wilson, Robbie S. and Seebacher, Frank (2016) Immune-challenged fish up-regulate their metabolic scope to support locomotion. PLoS ONE, 11 11: . doi:10.1371/journal.pone.0166028


Author Bonneaud, Camille
Wilson, Robbie S.
Seebacher, Frank
Title Immune-challenged fish up-regulate their metabolic scope to support locomotion
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2016-11-01
Sub-type Article (original research)
DOI 10.1371/journal.pone.0166028
Open Access Status DOI
Volume 11
Issue 11
Total pages 14
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Energy-based trade-offs occur when investment in one fitness-related trait diverts energy away from other traits. The extent to which such trade-offs are shaped by limits on the rate of conversion of energy ingested in food (e.g. carbohydrates) into chemical energy (ATP) by oxidative metabolism rather than by the amount of food ingested in the first place is, however, unclear. Here we tested whether the ATP required for mounting an immune response will lead to a trade-off with ATP available for physical activity in mosquitofish (Gambusia holbrooki). To this end, we challenged fish either with lipopolysaccharide (LPS) from E. coli or with Sheep Red Blood Cells (SRBC), and measured oxygen consumption at rest and during swimming at maximum speed 24h, 48h and 7 days post-challenge in order to estimate metabolic rates. Relative to saline-injected controls, only LPS-injected fish showed a significantly greater resting metabolic rate two days post-challenge and significantly higher maximal metabolic rates two and seven days post-challenge. This resulted in a significantly greater metabolic scope two days post-challenge, with LPS-fish transiently overcompensating by increasing maximal ATP production more than would be required for swimming in the absence of an immune challenge. LPS-challenged fish therefore increased their production of ATP to compensate physiologically for the energetic requirements of immune functioning. This response would avoid ATP shortages and allow fish to engage in an aerobically-challenging activity (swimming) even when simultaneously mounting an immune response. Nevertheless, relative to controls, both LPS- and SRBC-fish displayed reduced body mass gain one week post-injection, and LPS-fish actually lost mass. The concomitant increase in metabolic scope and reduced body mass gain of LPS-challenged fish indicates that immuneassociated trade-offs are not likely to be shaped by limited oxidative metabolic capacities, but may instead result from limitations in the acquisition, assimilation or efficient use of resources.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biological Sciences Publications
 
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