Viper venom botox: the molecular origin and evolution of the waglerin peptides used in anti-wrinkle skin cream

Debono, Jordan, Xie, Bing, Violette, Aude, Fourmy, Rudy, Jaeger, Marc and Fry, Bryan G. (2016) Viper venom botox: the molecular origin and evolution of the waglerin peptides used in anti-wrinkle skin cream. Journal of Molecular Evolution, 1-4. doi:10.1007/s00239-016-9764-6


Author Debono, Jordan
Xie, Bing
Violette, Aude
Fourmy, Rudy
Jaeger, Marc
Fry, Bryan G.
Title Viper venom botox: the molecular origin and evolution of the waglerin peptides used in anti-wrinkle skin cream
Journal name Journal of Molecular Evolution   Check publisher's open access policy
ISSN 0022-2844
1432-1432
Publication date 2016-11-18
Sub-type Article (original research)
DOI 10.1007/s00239-016-9764-6
Open Access Status Not yet assessed
Start page 1
End page 4
Total pages 4
Place of publication New York, NY, United States
Publisher Springer New York LLC
Language eng
Formatted abstract
The molecular origin of waglerin peptides has remained enigmatic despite their industrial application in skin cream products to paralyse facial muscles and thus reduce the incidence of wrinkles. Here we show that these neurotoxic peptides are the result of de novo evolution within the prepro region of the C-type natriuretic peptide gene in Tropidolaemus venoms, at a site distinct from the domain encoding for the natriuretic peptide. It is the same region that yielded the azemiopsin peptides from Azemiops feae, indicative of a close relationship of this toxin gene between these two genera. The precursor region for the molecular evolution is a biodiversity hotspot that has yielded other novel bioactive peptides with novel activities. We detail the diversity of components in this and other species in order to explore what characteristics enable it to be such a biodiscovery treasure trove. The unusual function of Tropidolaemus venoms may have been selected for due to evolutionary pressures brought about by a high likelihood of prey escape.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biological Sciences Publications
 
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