Molecular genetic contributions to social deprivation and household income in UK biobank

Hill, W. David, Hagenaars, Saskia P., Marioni, Riccardo E., Harris, Sarah E., Liewald, David C. M., Davies, Gail, Okbay, Aysu, McIntosh, Andrew M., Gale, Catharine R. and Deary, Ian J. (2016) Molecular genetic contributions to social deprivation and household income in UK biobank. Current Biology, 26 22: 3083-3089. doi:10.1016/j.cub.2016.09.035


Author Hill, W. David
Hagenaars, Saskia P.
Marioni, Riccardo E.
Harris, Sarah E.
Liewald, David C. M.
Davies, Gail
Okbay, Aysu
McIntosh, Andrew M.
Gale, Catharine R.
Deary, Ian J.
Title Molecular genetic contributions to social deprivation and household income in UK biobank
Journal name Current Biology   Check publisher's open access policy
ISSN 0960-9822
1879-0445
Publication date 2016-11-21
Sub-type Article (original research)
DOI 10.1016/j.cub.2016.09.035
Open Access Status Not yet assessed
Volume 26
Issue 22
Start page 3083
End page 3089
Total pages 7
Place of publication Cambridge, MA, United States
Publisher Cell Press
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
1100 Agricultural and Biological Sciences
Abstract Individuals with lower socio-economic status (SES) are at increased risk of physical and mental illnesses and tend to die at an earlier age [1–3]. Explanations for the association between SES and health typically focus on factors that are environmental in origin [4]. However, common SNPs have been found collectively to explain around 18% of the phenotypic variance of an area-based social deprivation measure of SES [5]. Molecular genetic studies have also shown that common physical and psychiatric diseases are partly heritable [6]. It is possible that phenotypic associations between SES and health arise partly due to a shared genetic etiology. We conducted a genome-wide association study (GWAS) on social deprivation and on household income using 112,151 participants of UK Biobank. We find that common SNPs explain 21% of the variation in social deprivation and 11% of household income. Two independent loci attained genome-wide significance for household income, with the most significant SNP in each of these loci being rs187848990 on chromosome 2 and rs8100891 on chromosome 19. Genes in the regions of these SNPs have been associated with intellectual disabilities, schizophrenia, and synaptic plasticity. Extensive genetic correlations were found between both measures of SES and illnesses, anthropometric variables, psychiatric disorders, and cognitive ability. These findings suggest that some SNPs associated with SES are involved in the brain and central nervous system. The genetic associations with SES obviously do not reflect direct causal effects and are probably mediated via other partly heritable variables, including cognitive ability, personality, and health.
Keyword Genetic correlation
Genetics
GWAS
Income
SES
Social deprivation
Socioeconomic status
UK Biobank
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID MC_UP_A620_1015
MC_U147574232
MC_UU_12011/2
MC_U147585819
BB/F019394/1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Queensland Brain Institute Publications
 
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