Mouse models in oncoimmunology

Zitvogel, Laurence, Pitt, Jonathan M., Daillere, Romain, Smyth, Mark J. and Kroemer, Guido (2016) Mouse models in oncoimmunology. Nature Reviews Cancer, 16 12: 759-773. doi:10.1038/nrc.2016.91


Author Zitvogel, Laurence
Pitt, Jonathan M.
Daillere, Romain
Smyth, Mark J.
Kroemer, Guido
Title Mouse models in oncoimmunology
Journal name Nature Reviews Cancer   Check publisher's open access policy
ISSN 1474-1768
1474-175X
Publication date 2016-12-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrc.2016.91
Open Access Status Not yet assessed
Volume 16
Issue 12
Start page 759
End page 773
Total pages 15
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Fundamental cancer research and the development of efficacious antineoplastic treatments both rely on experimental systems in which the relationship between malignant cells and immune cells can be studied. Mouse models of transplantable, carcinogen-induced or genetically engineered malignancies — each with their specific advantages and difficulties — have laid the foundations of oncoimmunology. These models have guided the immunosurveillance theory that postulates that evasion from immune control is an essential feature of cancer, the concept that the long-term effects of conventional cancer treatments mostly rely on the reinstatement of anticancer immune responses and the preclinical development of immunotherapies, including currently approved immune checkpoint blockers. Specific aspects of pharmacological development, as well as attempts to personalize cancer treatments using patient-derived xenografts, require the development of mouse models in which murine genes and cells are replaced with their human equivalents. Such 'humanized' mouse models are being progressively refined to characterize the leukocyte subpopulations that belong to the innate and acquired arms of the immune system as they infiltrate human cancers that are subjected to experimental therapies. We surmise that the ever-advancing refinement of murine preclinical models will accelerate the pace of therapeutic optimization in patients.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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