Pharmacokinetic assessment of the marker active metabolites 4-methyl-amino-antipyrine and 4-acetyl-amino-antipyrine after intravenous and intramuscular injection of metamizole (Dipyrone) in healthy donkeys

Aupanun, Sawinee, Laus, Fulvio, Poapolathep, Amnart, Owen, Helen, Vullo, Cecilia, Faillace, Vanessa and Giorgi, Mario (2016) Pharmacokinetic assessment of the marker active metabolites 4-methyl-amino-antipyrine and 4-acetyl-amino-antipyrine after intravenous and intramuscular injection of metamizole (Dipyrone) in healthy donkeys. Journal of Equine Veterinary Science, 47 55-61. doi:10.1016/j.jevs.2016.08.005

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Aupanun, Sawinee
Laus, Fulvio
Poapolathep, Amnart
Owen, Helen
Vullo, Cecilia
Faillace, Vanessa
Giorgi, Mario
Title Pharmacokinetic assessment of the marker active metabolites 4-methyl-amino-antipyrine and 4-acetyl-amino-antipyrine after intravenous and intramuscular injection of metamizole (Dipyrone) in healthy donkeys
Journal name Journal of Equine Veterinary Science   Check publisher's open access policy
ISSN 0737-0806
1542-7412
Publication date 2016-12-01
Sub-type Article (original research)
DOI 10.1016/j.jevs.2016.08.005
Open Access Status File (Author Post-print)
Volume 47
Start page 55
End page 61
Total pages 7
Place of publication Maryland Heights, MO, United States
Publisher W.B. Saunders
Collection year 2017
Language eng
Formatted abstract
Metamizole (MT) is an analgesic and antipyretic drug labelled for use in humans, horses, cattle, swine, and dogs in some countries. Metamizole is rapidly hydrolyzed to the active primary metabolite 4-methyl-amino-antipyrine (MAA). MAA is formed in much larger amounts compared to other minor metabolites. Among the other secondary metabolites, 4-amino-antipyrine (AA) is also relatively active. The aim of this research was to evaluate the pharmacokinetic profiles of MAA and AA after administration of 25 mg/kg MT by intravenous (IV) and intramuscular (IM) routes in healthy donkeys. Six jennies were randomly allocated to two equally sized treatment groups according to a 2 × 2 crossover study. Blood was collected at predetermined times within 24 hours, and plasma was analyzed by a validated HPLC UV method. Plasma concentrations of MAA after IV and IM administrations of MT were detectable from 5 minutes to 10 hours in all the donkeys. Plasma concentrations of AA were detectable from 5 minutes to 8 hours, but in smaller amounts. Cmax (P < .01), AUC0-last, AUC0-∞, AUMC0-last, and MRT (P < .05) were statistically different between the IV and IM groups. The AUCIM/AUCIV ratio of MAA was 1.37. The AA concentrations were lower than those found for MAA. The AA plasma versus time curves profiles after the two routes of administration of MT were variable (within the groups) and different (between the groups). Tmax, λz, and AUC0-last were found to be statistically different between the groups (P < .05). The AUCIM AA/AUCIV AA ratio was 2.26.
Keyword Analgesic
Dipyrone
Donkey
Metabolism
Pharmacokinetic
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Veterinary Science Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 06 Dec 2016, 10:46:08 EST by System User on behalf of Learning and Research Services (UQ Library)