Inotropes do not increase cardiac output or cerebral blood flow in preterm piglets

Eiby, Yvonne A., Shrimpton, Nicole Y. , Wright, Ian M. R. , Lumbers, Eugenie R., Colditz, Paul B. , Duncombe, Greg J. and Lingwood, Barbara E.  (2016) Inotropes do not increase cardiac output or cerebral blood flow in preterm piglets. Pediatric Research, 80 6: 870-879. doi:10.1038/pr.2016.156

Author Eiby, Yvonne A.
Shrimpton, Nicole Y. 
Wright, Ian M. R. 
Lumbers, Eugenie R.
Colditz, Paul B. 
Duncombe, Greg J.
Lingwood, Barbara E. 
Title Inotropes do not increase cardiac output or cerebral blood flow in preterm piglets
Journal name Pediatric Research   Check publisher's open access policy
ISSN 1530-0447
Publication date 2016-12-01
Sub-type Article (original research)
DOI 10.1038/pr.2016.156
Open Access Status Not yet assessed
Volume 80
Issue 6
Start page 870
End page 879
Total pages 10
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Collection year 2017
Language eng
Formatted abstract
Background: The preterm newborn is at high risk of developing cardiovascular compromise during the first day of life and this is associated with increased risk of brain injury. Standard treatments are volume expansion and administration of inotropes, typically dopamine and/or dobutamine, but there is limited evidence that inotropes improve clinical outcomes. This study investigated the efficacy of dopamine and dobutamine for the treatment of cardiovascular compromise in the preterm newborn using a piglet model.

Methods: Preterm and term piglets were assigned to either dopamine, dobutamine or control infusions. Heart rate, left ventricular contractility, cardiac output, blood pressure, and cerebral and regional blood flows were measured during baseline, low (10 μg/kg/h), and high (20 μg/kg/h) dose infusions.

Results: At baseline, preterm piglets had lower cardiac contractility, cardiac output, blood pressure, and cerebral blood flow compared to term piglets. The response of preterm piglets to either dopamine or dobutamine administration was less than in term piglets. In both preterm and term piglets, cardiac output and cerebral blood flow were unaltered by either inotrope.

Conclusion: In order to provide better cardiovascular support, it may be necessary to develop treatments that target receptors with a more mature profile than adrenoceptors in the preterm newborn.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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