Epicardial adipose tissue volume and left ventricular myocardial function using 3-dimensional speckle tracking echocardiography

Ng, Arnold C. T., Goo, Shi Yi, Roche, Nicole, van der Geest, Rob J. and Wang, William Y. S. (2016) Epicardial adipose tissue volume and left ventricular myocardial function using 3-dimensional speckle tracking echocardiography. Canadian Journal of Cardiology, 32 12: 1485-1492. doi:10.1016/j.cjca.2016.06.009

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Author Ng, Arnold C. T.
Goo, Shi Yi
Roche, Nicole
van der Geest, Rob J.
Wang, William Y. S.
Title Epicardial adipose tissue volume and left ventricular myocardial function using 3-dimensional speckle tracking echocardiography
Journal name Canadian Journal of Cardiology   Check publisher's open access policy
ISSN 0828-282X
1916-7075
Publication date 2016-12-01
Sub-type Article (original research)
DOI 10.1016/j.cjca.2016.06.009
Open Access Status File (Author Post-print)
Volume 32
Issue 12
Start page 1485
End page 1492
Total pages 8
Place of publication New York, NY, United States
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
Background: Although epicardial adipose tissue (EAT) volume is associated with increased incidence of coronary artery disease (CAD), its role in myocardial systolic dysfunction is unclear. The present study aimed to identify independent determinants of EAT volume in patients without obstructive CAD, and to evaluate the association between EAT volume (vs other measures of obesity) and myocardial systolic strain analysis.

Methods: We prospectively recruited 130 patients without obstructive CAD on contrast-enhanced cardiac computed tomography imaging and normal left ventricular ejection fraction on 3-dimensional (3D) echocardiography. EAT volume was quantified from cardiac computed tomography imaging, and 3D multidirectional (longitudinal, circumferential, radial, and area) strain were measured.

Results: The mean EAT volume was 97.5 ± 43.7 cm3. In multivariable analysis, measures of obesity (body mass index [P = 0.007] and waist/hip ratio [P = 0.001]) were independently associated with larger EAT volume. EAT volume was correlated with 3D global longitudinal (r = 0.601; P < 0.001), circumferential (r = 0.375; P < 0.001), radial (r = −0.546; P < 0.001), and area (r = 0.558; P < 0.001) strain. In multivariable analyses, epicardial fat volume was the strongest predictor of 3D global longitudinal (standardized β = 0.512; P < 0.001), circumferential (standardized β = 0.242; P = 0.006), radial (standardized β = −0.422; P < 0.001), and area (standardized β = 0.428; P < 0.001) strain. In contrast, other measures of obesity including body mass index and waist/hip ratio were not independent determinants of 3D multidirectional global strain (all P > 0.05).

Conclusions:
EAT volume is independently associated with impaired myocardial systolic function despite preserved 3D left ventricular ejection fraction and absence of obstructive CAD, and might play a significant role in the pathophysiology of diabetic, obesity, and metabolic heart disease.
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Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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