It takes nerve to fight back: the significance of neural innervation of the bone marrow and spleen for immune function

Jung, Won-Cheol, Levesque, Jean-Pierre and Ruitenberg, Marc J. (2017) It takes nerve to fight back: the significance of neural innervation of the bone marrow and spleen for immune function. Seminars in Cell and Developmental Biology, 61 60-70. doi:10.1016/j.semcdb.2016.08.010


Author Jung, Won-Cheol
Levesque, Jean-Pierre
Ruitenberg, Marc J.
Title It takes nerve to fight back: the significance of neural innervation of the bone marrow and spleen for immune function
Journal name Seminars in Cell and Developmental Biology   Check publisher's open access policy
ISSN 1096-3634
1084-9521
Publication date 2017-01-01
Sub-type Article (original research)
DOI 10.1016/j.semcdb.2016.08.010
Open Access Status Not yet assessed
Volume 61
Start page 60
End page 70
Total pages 11
Place of publication London, United Kingdom
Publisher Academic Press
Language eng
Abstract Inflammation is a natural part of wound healing but it can also cause secondary (bystander) damage and/or negatively interfere with endogenous repair mechanisms if non-resolving. Regulation of inflammation is traditionally looked at from the perspective of danger signals, cytokines and chemokines, and their respective receptors. A neuronal contribution to the regulation of inflammation is, however, increasingly appreciated, and this has important implications for the bodily response under conditions where the nervous system itself may be damaged. In this review article, we provide an up-to-date overview of the current literature on neural innervation of primary and secondary lymphoid organs, focusing in particular on the bone marrow and spleen, its significance in relation to immune function and, lastly, also briefly discussing how a major neurotraumatic event like spinal cord injury (SCI) may impact on this.
Keyword Immunity
Hematopoiesis
Autonomic nervous system
Sensory feedback
Neuropeptide
Neurotransmitter
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes EPUB PMCID: 27523920 Mater UQ Affiliated: Levesque

 
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Created: Mon, 05 Dec 2016, 22:53:00 EST by Julia McCabe on behalf of Learning and Research Services (UQ Library)