Structural and functional brain changes following four weeks of unimanual motor training: evidence from behaviour, neural stimulation, cortical thickness and functional MRI

Sale, Martin V., Reid, Lee B., Cocchi, Luca, Pagnozzi, Alex M., Rose, Stephen E. and Mattingley, Jason B. (2016) Structural and functional brain changes following four weeks of unimanual motor training: evidence from behaviour, neural stimulation, cortical thickness and functional MRI. bioRxiv, . doi:10.1101/088302


Author Sale, Martin V.
Reid, Lee B.
Cocchi, Luca
Pagnozzi, Alex M.
Rose, Stephen E.
Mattingley, Jason B.
Title Structural and functional brain changes following four weeks of unimanual motor training: evidence from behaviour, neural stimulation, cortical thickness and functional MRI
Journal name bioRxiv
Publication date 2016-01-01
Sub-type Other
DOI 10.1101/088302
Open Access Status DOI
Total pages 37
Abstract Although different aspects of neuroplasticity can be quantified with behavioural probes, brain stimulation, and brain imaging assessments, no study to date has combined all these approaches into one comprehensive assessment of brain plasticity. Here, 24 healthy right-handed participants practised a sequence of finger-thumb opposition movements for 10 minutes each day with their left hand. After four weeks, performance for the practised sequence improved significantly (p < 0.05 FWE) relative to a matched control sequence, with both the left (mean increase: 53.0% practised, 6.5% control) and right (21.0%; 15.8%) hands. Training also induced significant (cluster p-FWE < 0.001) reductions in functional MRI activation for execution of the learned sequence, relative to the control sequence. These changes were observed as clusters in the premotor and supplementary motor cortices (right hemisphere, 301 voxel cluster; left hemisphere 700 voxel cluster), as well as sensorimotor cortices and superior parietal lobules (right hemisphere 864 voxel cluster; left hemisphere, 1947 voxel cluster). Transcranial magnetic stimulation over the right (‘trained’) primary motor cortex yielded a 58.6% mean increase in a measure of motor evoked potential amplitude, as recorded at the left abductor pollicis brevis muscle. Cortical thickness analyses based on structural MRI suggested changes in the rightprecentral gyrus, right post central gyrus, right dorsolateral prefrontal cortex and potentially the right supplementary motor area. Such findings are consistent with LTP-like neuroplastic changes in areas that were already responsible for finger sequence execution, rather than improved recruitment of previously non-utilised tissue.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Mon, 05 Dec 2016, 22:14:51 EST by Dr Martin Sale on behalf of School of Health & Rehabilitation Sciences